Mr. Alves and Ms Santiago contributed equally to this work.
Creatine Supplementation in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial†
Article first published online: 26 AUG 2013
Copyright © 2013 by the American College of Rheumatology
Arthritis Care & Research
Volume 65, Issue 9, pages 1449–1459, September 2013
How to Cite
Alves, C. R. R., Santiago, B. M., Lima, F. R., Otaduy, M. C. G., Calich, A. L., Tritto, A. C. C., de Sá Pinto, A. L., Roschel, H., Leite, C. C., Benatti, F. B., Bonfá, E. and Gualano, B. (2013), Creatine Supplementation in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial. Arthritis Care Res, 65: 1449–1459. doi: 10.1002/acr.22020
ClinicalTrials.gov identifier: NCT00749983.
- Issue published online: 26 AUG 2013
- Article first published online: 26 AUG 2013
- Accepted manuscript online: 1 APR 2013 12:32PM EST
- Manuscript Accepted: 20 MAR 2013
- Manuscript Received: 10 OCT 2012
- FAPESP. Grant Number: FBB: 2011/08302-0
To investigate the efficacy and safety of creatine supplementation in fibromyalgia patients.
A 16-week, randomized, double-blind, placebo-controlled, parallel-group trial was conducted. Fibromyalgia patients were randomly assigned to receive either creatine monohydrate or placebo in a double-blind manner. The patients were evaluated at baseline and after 16 weeks. Muscle function, aerobic conditioning, cognitive function, quality of sleep, quality of life, kidney function, and adverse events were assessed. Muscle phosphorylcreatine content was measured through 31P magnetic resonance spectroscopy.
After the intervention, the creatine group presented higher muscle phosphorylcreatine content when compared with the placebo group (+80.3% versus −2.7%; P = 0.04). Furthermore, the creatine group presented greater muscle strength than the placebo group in the leg press and chest press exercises (+9.8% and +1.2% for creatine versus −0.5% and −7.2% for placebo, respectively; P = 0.02 and P = 0.002, respectively). Isometric strength was greater in the creatine group than in the placebo group (+6.4% versus −3.2%; P = 0.007). However, no general changes were observed in aerobic conditioning, pain, cognitive function, quality of sleep, and quality of life. Food intake remained unaltered and no side effects were reported.
Creatine supplementation increased intramuscular phosphorylcreatine content and improved lower- and upper-body muscle function, with minor changes in other fibromyalgia features. These findings introduce creatine supplementation as a useful dietary intervention to improve muscle function in fibromyalgia patients.