Ms. Muggli has received consulting fees, speaking fees, and/or honoraria (less than $10,000 each) from the Swiss Ankylosing Spondylitis Foundation.
Effect of Cardiovascular Training on Fitness and Perceived Disease Activity in People With Ankylosing Spondylitis†
Article first published online: 28 OCT 2013
Copyright © 2013 by the American College of Rheumatology
Arthritis Care & Research
Volume 65, Issue 11, pages 1844–1852, November 2013
How to Cite
Niedermann, K., Sidelnikov, E., Muggli, C., Dagfinrud, H., Hermann, M., Tamborrini, G., Ciurea, A. and Bischoff-Ferrari, H. (2013), Effect of Cardiovascular Training on Fitness and Perceived Disease Activity in People With Ankylosing Spondylitis. Arthritis Care Res, 65: 1844–1852. doi: 10.1002/acr.22062
ClinicalTrials.gov identifier: NCT00913302.
- Issue published online: 28 OCT 2013
- Article first published online: 28 OCT 2013
- Accepted manuscript online: 8 JUL 2013 09:35AM EST
- Manuscript Accepted: 6 JUN 2013
- Manuscript Received: 22 DEC 2012
- University Hospital Zurich (Department of Rheumatology and Institute of Physical Medicine)
- Schweizerische Vereinigung Morbus Bechterew, Zurich
- Böhni Foundation for Research in Rheumatology, Zurich
- Zurich Rheumatology Foundation
- Swiss Physiotherapy Association
- Physiotherapie Wissenschaften Foundation
Several studies suggest that patients with ankylosing spondylitis (AS) have an increased risk of cardiovascular disease. This study aimed to evaluate the effects of a 12-week, individually monitored, with moderate heart rate level intensity cardiovascular training on cardiovascular fitness and perceived disease activity in AS patients.
Patients diagnosed with AS according to the modified New York criteria were randomized to either cardiovascular training or attention control. The training group performed 3 cardiovascular training units per week. All participants attended 1 weekly usual care flexibility training session. Attention control contained regular discussion groups on coping strategies. Adherence was self-monitored. Assessments were performed at baseline and after the intervention period of 3 months. Physical fitness was the primary end point, measured in watts using a submaximal bicycle test following the physical work capacity 75% protocol. All analyses controlled for sex, age, body mass index, baseline fitness and physical activity levels, and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI).
Of 106 AS patients enrolled, 40% were women and the mean ± SD age was 49 ± 12 years. A total of 74.6% of the training group reported exercising at least 3 times a week. At the 3-month followup, the fitness level in the training group was significantly higher than in the control group (mean ± SE 90.32W ± 4.52W versus 109.84W ± 4.72W; P = 0.001), independent of other covariates. The mean BASDAI total score was 0.31 points lower (P = 0.31) in the training group, reaching significance for the peripheral pain subscore (1.19; P = 0.01) but not for back pain or fatigue.
Cardiovascular training, in addition to flexibility exercise, increased fitness in AS patients and reduced their peripheral pain.