The findings and conclusions herein are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
Meeting Physical Activity Guidelines and the Risk of Incident Knee Osteoarthritis: A Population-Based Prospective Cohort Study†
Version of Record online: 24 DEC 2013
Copyright © 2014 by the American College of Rheumatology
Arthritis Care & Research
Volume 66, Issue 1, pages 139–146, January 2014
How to Cite
Barbour, K. E., Hootman, J. M., Helmick, C. G., Murphy, L. B., Theis, K. A., Schwartz, T. A., Kalsbeek, W. D., Renner, J. B. and Jordan, J. M. (2014), Meeting Physical Activity Guidelines and the Risk of Incident Knee Osteoarthritis: A Population-Based Prospective Cohort Study. Arthritis Care Res, 66: 139–146. doi: 10.1002/acr.22120
- Issue online: 24 DEC 2013
- Version of Record online: 24 DEC 2013
- Accepted manuscript online: 27 AUG 2013 03:25PM EST
- Manuscript Accepted: 15 JUL 2013
- Manuscript Received: 25 FEB 2013
- Centers for Disease Control and Prevention/Association of Schools of Public Health. Grant Numbers: Cooperative agreements S043, S1734, S3486
- National Institute of Arthritis and Musculoskeletal and Skin Diseases Multipurpose Arthritis and Musculoskeletal Disease Center. Grant Number: 5-P60-AR30701
- National Institute of Arthritis and Musculoskeletal and Skin Diseases Multidisciplinary Clinical Research Center. Grant Number: 5-P60-AR49465-03
Knee osteoarthritis (OA) is a leading cause of disability and joint pain. Although other risk factors of knee OA have been identified, how physical activity affects incident knee OA remains unclear.
Using data from the first (1999–2004) and second (2005–2010) followup periods of the Johnston County Osteoarthritis Project study, we tested the association between meeting physical activity guidelines and incident knee outcomes among 1,522 adults ages ≥45 years. The median followup time was 6.5 years (range 4.0–10.2 years). Physical activity at baseline (moderate-equivalent physical activity minutes/week) was calculated using the Minnesota Leisure Time Physical Activity questionnaire. Incident knee radiographic OA (ROA) was defined as the development of Kellgren/Lawrence grade ≥2 in a knee at followup. Incident knee symptomatic ROA (sROA) was defined as the development of ROA and symptoms in at least 1 knee at followup. Weibull regression modeling was used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for interval-censored data.
In multivariable models, meeting the 2008 Department of Health and Human Services (HHS) physical activity guidelines (≥150 minutes/week) was not significantly associated with ROA (HR 1.20 [95% CI 0.92–1.56]) or sROA (HR 1.24 [95% CI 0.87–1.76]). Adults in the highest level (≥300 minutes/week) of physical activity had a higher risk of knee ROA and sROA compared with inactive (0 to <10 minutes/week) participants; however, these associations were not statistically significant (HR 1.62 [95% CI 0.97–2.68] and HR 1.42 [95% CI 0.76–2.65], respectively).
Meeting the HHS physical activity guidelines was not associated with incident knee ROA or sROA in a cohort of middle-aged and older adults.