Dr. McAlindon has received consulting fees, speaking fees, and/or honoraria (less than $10,000 each) from Flexion, Sanofi, Samumed, and AbbVie; receives royalties from Mytrus for online clinical trials; and has received research grants from the NIH, American College of Rheumatology, and Croma.
Milk Consumption and Progression of Medial Tibiofemoral Knee Osteoarthritis: Data From the Osteoarthritis Initiative
Version of Record online: 27 MAY 2014
Copyright © 2014 by the American College of Rheumatology
Arthritis Care & Research
Volume 66, Issue 6, pages 802–809, June 2014
How to Cite
Lu, B., Driban, J. B., Duryea, J., McAlindon, T., Lapane, K. L. and Eaton, C. B. (2014), Milk Consumption and Progression of Medial Tibiofemoral Knee Osteoarthritis: Data From the Osteoarthritis Initiative. Arthritis Care Res, 66: 802–809. doi: 10.1002/acr.22297
- Issue online: 27 MAY 2014
- Version of Record online: 27 MAY 2014
- Accepted manuscript online: 6 APR 2014 11:00PM EST
- Manuscript Accepted: 28 JAN 2014
- Manuscript Received: 28 JUN 2013
- National Heart, Lung, and Blood Institute. Grant Numbers: contract HHSN268201000020C, reference BAA-NHLBI-AR-10-06)
- NIH, a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Grant Numbers: (N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262
- Pfizer, Inc.
- Novartis Pharmaceuticals Corporation
- Merck Research Laboratories
- Foundation for the NIH
Milk consumption has long been recognized for its important role in bone health, but its role in the progression of knee osteoarthritis (OA) is unclear. We examined the prospective association of milk consumption with radiographic progression of knee OA.
In the Osteoarthritis Initiative, 2,148 participants (3,064 knees) with radiographic knee OA and dietary data at baseline were followed up to 12, 24, 36, and 48 months. Milk consumption was assessed with a Block Brief Food Frequency Questionnaire completed at baseline. To evaluate progression of OA, we used quantitative joint space width (JSW) between the medial femur and tibia of the knee based on plain radiographs. The multivariate linear models for repeated measures were used to test the independent association between milk intake and the decrease in JSW over time, while adjusting for baseline disease severity, body mass index, dietary factors, and other potential confounders.
We observed a significant dose-response relationship between baseline milk intake and adjusted mean decrease of JSW in women (P = 0.014 for trend). With increasing levels of milk intake (none, ≤3, 4–6, and ≥7 glasses/week), the mean decreases of JSW were 0.38 mm, 0.29 mm, 0.29 mm, and 0.26 mm, respectively. In men, we observed no significant association between milk consumption and the decreases of JSW.
Our results suggest that frequent milk consumption may be associated with reduced OA progression in women. Replication of these novel findings in other prospective studies demonstrating the increase in milk consumption leads to delay in knee OA progression are needed.