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Parental Influence on Systemic Sclerosis†
Version of Record online: 27 JAN 2015
Copyright © 2015 by the American College of Rheumatology
Arthritis Care & Research
Volume 67, Issue 2, pages 310–312, February 2015
How to Cite
Frech, T. M., Pimentel, R., Mineau, G., Sawitzke, A., Penmetsa, G. and Wong, J. (2015), Parental Influence on Systemic Sclerosis. Arthritis Care Res, 67: 310–312. doi: 10.1002/acr.22352
- Issue online: 27 JAN 2015
- Version of Record online: 27 JAN 2015
- Accepted manuscript online: 22 APR 2014 12:34PM EST
- Manuscript Accepted: 15 APR 2014
- Manuscript Received: 17 SEP 2013
- Huntsman Cancer Institute
- National Center for Research Resources
- National Center for Advancing Translational Sciences. Grant Number: 8-UL-1TR000105, formerly UL-1RR025764
To examine parental influence on the development of systemic sclerosis (SSc; scleroderma). We designed 3 studies: mitochondrial inheritance, birth order (a possible surrogate marker for microchimerism), and paternal age at conception (a possible surrogate for telomere erosion) to examine their association with development of SSc.
SSc was defined by International Classification of Diseases, Ninth and Tenth Revision codes (ICD-9 710.1 and ICD 10 M34.0, M34.1, and M34.9) and identified from statewide discharge data, University of Utah Health Science Center Enterprise Data Warehouse (UUHSC), and death certificates that were linked to the Utah Population Database (UPDB) for analysis. Mitochondrial inheritance was evaluated by conditional logistic regression and population attributable risk using familial standardized incidence ratio as the covariate. Chi-square test and logistic regression were used to evaluate birth order and maternal/paternal age at conception of the SSc proband.
We found 1,947 unique SSc patients from UUHSC and UPDB. We selected 5 controls per case (n = 9,115), matched by birth year and sex. Mitochondrial inheritance analysis indicated no evidence to suggest SSc was associated with mitochondrial inheritance. Birth order and maternal/paternal age at conception analysis results show that they also do not significantly affect SSc development.
Results suggest that although heritable risk of SSc is observed, mitochondrial inheritance, birth order, and parental age are not likely responsible for pathogenesis.