Systemic Lupus Prevalence in Sweden in 2010: What do national registers say?
Copyright © 2014 American College of Rheumatology
- Accepted manuscript online: 22 APR 2014 12:34PM EST
- Manuscript Accepted: 15 APR 2014
- Manuscript Revised: 20 MAR 2014
- Manuscript Received: 13 FEB 2014
- Strategic Research Program in Epidemiology at Karolinska Institutet. CS acknowledges the County Council of Östergötland
- Swedish Society for Medical Research
- Swedish Rheumatism Association
- Swedish Society of Medicine
- King Gustaf V 80-year Foundation
- Swedish Research Council, Swedish Rheumatism Association, King Gustaf V 80-year Foundation, and Combine
- Stockholm County Council
- Swedish Research Council, the Swedish Heart-Lung Foundation
- Swedish Rheumatism Foundation
- The King Gustaf V 80th Birthday Fund
- Cited By
- Systemic Lupus Erythematosus;
- Health services research
Objective: Worldwide prevalence estimates of systemic lupus erythematosus (SLE) range from 3-207 per 100,000 depending on region and population, SLE definition, case sources and other methodological considerations. We aimed to determine the prevalence of SLE in Sweden on January 1, 2010 using population-based registers.
Methods: Linking multiple national registers we identified all possible inpatient and outpatient visits with SLE-specific discharge diagnoses and relevant prescription dispensations among living individuals registered in Sweden on January 1, 2010. SLE was defined from a lenient classification (requiring only a single visit) to stricter definitions, which required multiple visits with a history of relevant specialist care and a dispensation for common SLE medications. Prevalence was calculated overall, and by sex, age (0-14, 15-49, 50+yrs, as well as in 5-year age groups), and county of residence.
Result: Overall prevalence ranged from 46 per 100,000 for the strictest definition to 85 per 100,000 for the least strict definition. As expected, SLE was more common among females (ranged from 79 to 144/100,000) than males (12-25/100,000) and varied by age. The up to four-fold variation by county was unexpected. Prevalence generally increased with age (2, 52, and 95 per 100,000 by increasing age group, 0-14/15-49/50+, using a moderately strict definition) and also varied by county.
Conclusion: Variations of prevalence by age and sex were consistent with previous studies and overall ranged from 46 to 85 per 100,000. We observed a surprising geographical variation in the prevalence of SLE in Sweden on January 1, 2010 according to multiple definitions. © 2014 American College of Rheumatology.