Communication

A Short-Term Bioresorbable Bone Filling Material Based on Hydroxyapatite, Chitosan, and Oxidized Starch Tested in a Novel Orthotopic Metaphyseal Mouse Model†

  1. Elias Volkmer1,*,
  2. Bettina Hoffmann2,
  3. Andreas Kokott2,
  4. Inga Drosse1,
  5. Anna-Katharina Neunhoeffer1,
  6. Florian Haasters1,
  7. Sebastian Seitz1,
  8. Michael Stengele1,
  9. Günther Ziegler2,
  10. Wolf Mutschler1,
  11. Matthias Schieker1,*

Article first published online: 29 JUN 2009

DOI: 10.1002/adem.200800351

Issue

Advanced Engineering Materials

Advanced Engineering Materials

Volume 11, Issue 8, pages B114–B121, August 2009

Additional Information

How to Cite

Volkmer, E., Hoffmann, B., Kokott, A., Drosse, I., Neunhoeffer, A.-K., Haasters, F., Seitz, S., Stengele, M., Ziegler, G., Mutschler, W. and Schieker, M. (2009), A Short-Term Bioresorbable Bone Filling Material Based on Hydroxyapatite, Chitosan, and Oxidized Starch Tested in a Novel Orthotopic Metaphyseal Mouse Model. Advanced Engineering Materials, 11: B114–B121. doi: 10.1002/adem.200800351

Author Information

  1. 1

    Experimental Surgery and Regenerative Medicine, Department of Surgery Ludwig Maximilians University (LMU) Nussbaumstrasse 20, D-80336 Munich, Germany

  2. 2

    Friedrich-Baur Research Institute for Biomaterials University of Bayreuth Ludwig-Thoma-Strasse 36c, D-95440 Bayreuth, Germany

*Experimental Surgery and Regenerative Medicine, Department of Surgery Ludwig Maximilians University (LMU) Nussbaumstrasse 20, D-80336 Munich, Germany.

  1. †

    This study is part of the doctoral thesis of A.-K.N. and published with permission of Ludwig Maximilians University, Munich. We thank Claudia Harbauer for her technical assistance with the histological sections, which were produced in collaboration with Prof. Putz (LMU, Munich).

Publication History

  1. Issue published online: 21 AUG 2009
  2. Article first published online: 29 JUN 2009
  3. Manuscript Revised: 7 MAY 2009
  4. Manuscript Received: 14 OCT 2008

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Keywords:

  • biomaterials;
  • bone filling materials;
  • hydroxyapatite;
  • small-aminal models

Graphical Abstract

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Despite significant advances in orthopedic surgery, no perfect bioresorbable bone-filling material has yet been clinically established. A new candidate material based on hydroxyapatite, chitosan and oxidised starch, which has the potential to covalently bind to bone in a watery milieu was tested in a new murine model. A special focus lies on the in vivo biocompatibility and bioresorbability of the new material.

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