This work was supported by a grant from the Korea Science & Engineering Foundation (Grant No. R01-2006-000-10432-0).
Dual-Growth-Factor-Releasing PCL Scaffolds for Chondrogenesis of Adipose-Tissue-Derived Mesenchymal Stem Cells†
Article first published online: 21 DEC 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Advanced Engineering Materials
How to Cite
Lim, S. M., Jang, S. H., Oh, S. H., Yuk, S. H., Im, G. I. and Lee, J. H. (2009), Dual-Growth-Factor-Releasing PCL Scaffolds for Chondrogenesis of Adipose-Tissue-Derived Mesenchymal Stem Cells . Adv. Eng. Mater.. doi: 10.1002/adem.200900153
- Issue published online: 21 DEC 2009
- Article first published online: 21 DEC 2009
- Manuscript Revised: 19 OCT 2009
- Manuscript Received: 28 MAY 2009
- Korea Science & Engineering Foundation. Grant Number: R01-2006-000-10432-0
Polycaprolactone/Pluronic F127 porous scaffolds are prepared using a modified melt-molding particulate-leaching method. The scaffolds are highly porous (about 90% porosity) and have open-cellular pore structures. Growth factors (TGF-β2, BMP-7 or dual TGF-β2/BMP-7) can be easily immobilized on the pore surfaces of the PCL/F127 scaffolds via binding with heparin. The growth-factor-immobilized scaffolds can induce the chondrogenesis of ATMSCs seeded onto them. Using TGF-β2 and BMP-7 growth factors together leads to a better chondrogenic differentiation behavior than using single-growth-factor immobilized scaffolds.