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Abstract

Polycaprolactone/Pluronic F127 porous scaffolds are prepared using a modified melt-molding particulate-leaching method. The scaffolds are highly porous (about 90% porosity) and have open-cellular pore structures. Growth factors (TGF-β2, BMP-7 or dual TGF-β2/BMP-7) can be easily immobilized on the pore surfaces of the PCL/F127 scaffolds via binding with heparin. The growth-factor-immobilized scaffolds can induce the chondrogenesis of ATMSCs seeded onto them. Using TGF-β2 and BMP-7 growth factors together leads to a better chondrogenic differentiation behavior than using single-growth-factor immobilized scaffolds.