This research was supported under the Australian Research Council's Discovery Projects funding scheme (project number DP0878785). The authors are grateful to Graham Ruhle for assistance with the compression testing.
Prototypes for Bone Implant Scaffolds Designed via Topology Optimization and Manufactured by Solid Freeform Fabrication†
Article first published online: 13 SEP 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Advanced Engineering Materials
Volume 12, Issue 11, pages 1106–1110, November, 2010
How to Cite
Challis, V. J., Roberts, A. P., Grotowski, J. F., Zhang, L.-C. and Sercombe, T. B. (2010), Prototypes for Bone Implant Scaffolds Designed via Topology Optimization and Manufactured by Solid Freeform Fabrication. Adv. Eng. Mater., 12: 1106–1110. doi: 10.1002/adem.201000154
- Issue published online: 26 NOV 2010
- Article first published online: 13 SEP 2010
- Manuscript Revised: 25 MAY 2010
- Manuscript Received: 7 MAY 2010
The linking of computational design with precision solid freeform fabrication has tremendous potential for producing tissue scaffolds with tailored properties. We consider a new approach to optimizing the architecture of scaffolds based on jointly maximizing scaffold stiffness and diffusive transport in the interconnected pores. The stiffness of the scaffolds is matched to that of bone by choosing a suitable scaffold porosity. Moreover, the templates can be scaled to achieve target pore sizes whilst preserving their elastic and diffusive properties. The resultant structures have two major design benefits. First, the scaffolds do not have directions of low stiffness. In contrast, the Young's modulus of conventional layered-grid designs can be 86% less under diagonally-aligned loads than under axis-aligned loads. Second, the mass of the scaffold is used efficiently throughout the structure rather than being clumped in non load-bearing regions. We fabricate prototypes of the implants using selective laser melting and test their elastic properties. Excellent agreement between theory and experiment provides important confirmation of the viability of this route to scaffold design and fabrication.