This work is fully supported by the GRF grant (CityU 120808), the Research Grants Council of Hong Kong, Hong Kong Special Administrative Region, China.
Spark Plasma Sintered Hydroxyapatite/Graphite Nanosheet and Hydroxyapatite/Multiwalled Carbon Nanotube Composites: Mechanical and in Vitro Cellular Properties†
Article first published online: 3 JAN 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Advanced Engineering Materials
Volume 13, Issue 4, pages 336–341, April, 2011
How to Cite
Zhu, J., Wong, H. M., Yeung, K. W. K. and Tjong, S. C. (2011), Spark Plasma Sintered Hydroxyapatite/Graphite Nanosheet and Hydroxyapatite/Multiwalled Carbon Nanotube Composites: Mechanical and in Vitro Cellular Properties. Adv. Eng. Mater., 13: 336–341. doi: 10.1002/adem.201000300
- Issue published online: 25 MAR 2011
- Article first published online: 3 JAN 2011
- Manuscript Accepted: 4 NOV 2010
- Manuscript Received: 29 SEP 2010
Hyroxyapatite (HA) and its nanocomposites reinforced with 0.5, 1, 1.5, and 2 wt% graphite nanosheets (GNs) and multi-walled carbon nanotubes (MWNTs) are fabricated by means of spark plasma sintering (SPS) process. The effects of MWNT and GN additions on the morphology, mechanical behavior, cell adhesion, and biocompatibility of HA were studied. Three-point-bending test shows that the bending strength of MWNT/HA nanocomposites increases with increasing MWNT content. However, the bending strength of GN/HA nanocomposites initially increases by adding 0.5 wt% GN, and then decreases markedly as the filler content increases. Cell culture and viability test results demonstrate that the GNs with diameters of several micrometers retard osteoblast cell adhesion and proliferation on the GN/HA nanocomposite. In contrast, the addition of 2 wt% MWNT to HA is beneficial to promote osteoblast adhesion and proliferation, thereby enhancing the biocompatibility of MWNT/HA nanocomposite.