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Dental caries, and tooth surface loss by erosion, abrasion, and attrition lead to irreversible loss of dental tissue. Enamel is a highly mineralized acellular tissue and cannot be regenerated after tooth eruption. Currently available restorative materials, such as composites, replace lost tooth structure and improve function and aesthetics. However, these materials have no structural similarities to natural tooth structure. The efficacy of an experimental biomimetic mineralization-kit was tested in a clinical pilot study in patients with hypersensitive teeth. Enamel defects were effectively treated by addition of a fluoroapatite layer.