Research Article

Enhanced Bone Cells Growth and Proliferation on TiO2 Nanotubular Substrates Treated by RF Plasma Discharge†

  1. Meena Mahmood1,
  2. Philip Fejleh1,
  3. Alokita Karmakar1,
  4. Ashley Fejleh1,
  5. Yang Xu1,
  6. Ganesh Kannarpady1,
  7. Hidetaka Ishihara1,
  8. Rajesh Sharma2,
  9. Zhongrui Li1,
  10. Anindya Ghosh3,
  11. Steve Trigwell4,
  12. Franklin D. Hardcastle5,
  13. Daniel Casciano1,
  14. Guna Selvaduray6,
  15. Alexandru S. Biris1,*

Article first published online: 11 NOV 2010

DOI: 10.1002/adem.201080072

Issue

Advanced Engineering Materials

Advanced Engineering Materials

Special Issue: 3D-Imaging of Materials and Systems

Volume 13, Issue 3, pages B95–B101, March, 2011

Additional Information

How to Cite

Mahmood, M., Fejleh, P., Karmakar, A., Fejleh, A., Xu, Y., Kannarpady, G., Ishihara, H., Sharma, R., Li, Z., Ghosh, A., Trigwell, S., Hardcastle, F. D., Casciano, D., Selvaduray, G. and Biris, A. S. (2011), Enhanced Bone Cells Growth and Proliferation on TiO2 Nanotubular Substrates Treated by RF Plasma Discharge. Adv. Eng. Mater., 13: B95–B101. doi: 10.1002/adem.201080072

Author Information

  1. 1

    Applied Science Department, University of Arkansas at Little Rock, UALR Nanotechnology Center 2801 S. University Ave, Little Rock, AR 72204, USA

  2. 2

    Arkansas State University, Renewable Energy Technology Program Jonesboro, AR 72467, USA

  3. 3

    Chemistry Department, University of Arkansas at Little Rock, UALR Nanotechnology Center 2801 S. University Ave, Little Rock, AR 72204, USA

  4. 4

    Applied Science and Technology, ASRC Aerospace ASRC-24, Kennedy Space Center, FL 32899, USA

  5. 5

    Department of Physical Sciences, Arkansas Tech University 1701 N. Boulder Ave., Russellville, AR 72801, USA

  6. 6

    Charles W. Davidson College of Engineering, San Jose State University San Jose, CA 95192-00890, USA

*Applied Science Department, University of Arkansas at Little Rock, UALR Nanotechnology Center 2801 S. University Ave, Little Rock, AR 72204, USA.

  1. †

    Acknowledgements, The authors would like to acknowledge the financial support of Arkansas Science and Technology Authority. The financial support from the US Army Telemedicine & Advanced Technology Research Center (TATRC) is acknowledged.

Publication History

  1. Issue published online: 1 MAR 2011
  2. Article first published online: 11 NOV 2010
  3. Manuscript Revised: 20 SEP 2010
  4. Manuscript Received: 9 JUL 2010

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (617K)

Keywords:

  • osteoblast cell proliferation;
  • plasma treatment;
  • TiO2 nanotubes

Abstract

Titanium implants are well known for their biocompatibility, especially if bioinertness is desired, due to the TiO2 native oxide which is thermodynamically and chemically very stable. One of the major problems with this material involve its inability to induce enhanced cellular adhesion and proliferation on its surface without complicated structural approaches, leading to the possible lack of bone-implant interfacial interaction and rejection. In order to potentially improve osseointegration of such implants self-assembled vertical and ordered nanotubular TiO2 arrays were fabricated by electrochemical anodization and were plasma treated under O2, N2, O2 + N2, and He gaseous environments and their properties analyzed by various analytical procedures. Osteoblast bone cells (MC3T3-E1) were grown on TiO2 nanotube-arrayed substrates and their proliferation was analyzed and quantified. Oxygen and nitrogen plasma treatments were found to significantly improve the proliferation of the bone cells over the TiO2 nanoarray substrates, with the O2 + N2 combination yielding the most significant improvements. These findings may be explained by the interactions between the cells and the changes in the surface chemistry induced by the O2 and N2 groups introduced by the plasma discharge treatment onto the TiO2 surfaces

View Full Article (HTML) Get PDF (617K)