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Polymers in Drug Delivery—State of the Art and Future Trends

Authors

  • Stefan Grund,

    1. Friedrich-Schiller-University Jena Institute of Pharmacy Department of Pharmaceutical Technology Otto-Schott-Straße 41 07745 Jena, (Germany)
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    • Both the authors have equally contributed.

  • Marius Bauer,

    1. Friedrich-Schiller-University Jena Institute of Pharmacy Department of Pharmaceutical Technology Otto-Schott-Straße 41 07745 Jena, (Germany)
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    • Both the authors have equally contributed.

  • Dagmar Fischer

    Corresponding author
    1. Friedrich-Schiller-University Jena Institute of Pharmacy Department of Pharmaceutical Technology Otto-Schott-Straße 41 07745 Jena, (Germany)
    • Friedrich-Schiller-University Jena Institute of Pharmacy Department of Pharmaceutical Technology Otto-Schott-Straße 41 07745 Jena, (Germany).
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  • The Thuringian Ministry for Education, Science, and Culture is gratefully acknowledged (grant #B514-09051, NanoConSens). The authors would like to thank Achim Aigner for careful and critical reading of the manuscript, and Juliane Kolbinger for the corrections of the manuscript.

Abstract

Advances in biotechnology, proteomics, and genomics, as well as the deeper understanding of the molecular and cellular bases of pathophysiological states, have allowed the development of novel drugs such as proteins, peptides, and nucleic acids as therapeutic strategies of the future. Their application, however, requires sophisticated drug delivery systems which can be used to alter the pharmacokinetics and release characteristics of drugs, and to increase tissue specificity and biocompatibility. In this context, polymers provide the most promising avenue in drug release control due to their favorable, adjustable characteristics, and possibilities for further modification. Advances in the biomedical sciences have had a significant impact on the design and development of new and intelligent drug delivery systems for more controlled and targeted drug application. This review summarizes the status quo of polymer use for drug delivery with a special focus on structure–property relationships and gives overviews of various polymers, the relevant parameters in drug delivery and the most promising trends in the future.

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