A special approach is required when applying common simulation techniques (e.g. finite elements methods) for vibro-acoustic analysis (natural and force vibrations, mode shapes) to cellular metals. While models using average values for Young's module and for the material density are not sufficiently precise – especially when the material is strongly inhomogeneous, in contrast, simulation using precise microstructure information is not time efficient. Therefore, the main challenge is to map the material microstructure information to the vibro-acoustic simulation model with acceptable efficiency. In this paper, a multiscale technique with representative volume elements is used for this purpose. The results from this approach are validated for a truck oil pan made from closed-cell aluminium foam with strong variations in the microstructure. The investigations show that with more detailed microstructure information the simulation precision can be improved significantly. The simulation results for the natural frequencies show a good agreement (to within 5%) with the values from experiment.