Communication

Bioactive Materials for Regenerative Medicine: Zeolite-Hydroxyapatite Bone Mimetic Coatings†

  1. Rajwant Singh Bedi2,
  2. Gabriel Chow3,
  3. Junlan Wang3,
  4. Laura Zanello4,
  5. Yushan S. Yan1,*

Article first published online: 21 OCT 2011

DOI: 10.1002/adem.201100170

Issue

Advanced Engineering Materials

Advanced Engineering Materials

Volume 14, Issue 3, pages 200–206, March 2012

Additional Information

How to Cite

Bedi, R. S., Chow, G., Wang, J., Zanello, L. and Yan, Y. S. (2012), Bioactive Materials for Regenerative Medicine: Zeolite-Hydroxyapatite Bone Mimetic Coatings. Adv. Eng. Mater., 14: 200–206. doi: 10.1002/adem.201100170

Author Information

  1. 1

    Department of Chemical Engineering, University of Delaware, Newark, DE 19716, (USA)

  2. 2

    Deptartment of Chemical and Environmental Engineering, University of California, Riverside, CA 92521, (USA)

  3. 3

    Department of Mechanical Engineering University of Washington, Seattle, 98195, (USA)

  4. 4

    Biochemistry Department, University of California Riverside, CA 92521, (USA)

*Department of Chemical Engineering, University of Delaware, Newark, DE 19716, (USA).

  1. †

    Supporting information is available from the Wiley Online Library or from the author.

Publication History

  1. Issue published online: 5 MAR 2012
  2. Article first published online: 21 OCT 2011
  3. Manuscript Revised: 20 JUL 2011
  4. Manuscript Received: 28 JUN 2011

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Abstract

We report the synthesis and characterization of a novel zeolite-hydroxyapatite composite coating on titanium alloys and stainless steel. The zeolite-hydroxyapatite coating is superhydrophilic and outperforms the state-of-the-art Ti6Al4V alloys in corrosion resistance tests in aggressive pitting NaCl media, phosphate buffer solution with BSA protein, as well as highly complex DMEM cell culture media. And the composite coating also eliminates the elastic modulus mismatch between coating and bone. In addition, the composite coating has an osteoconductive and osteoinductive effect on hFOBs, indicating that it may enhance osteointegration of implants and speed up post-surgical recovery, and thus reduce the need for recurring implant replacement surgeries. Replacing titanium with zeolite-hydroxyapatite coated steel can also significantly reduce implant cost while improving implant lifespan.

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