While the fatigue behavior of die cast aluminum as well as welded aluminum wrought alloys have been subject of several studies, no systematic work has been carried out on hybrid structures made as a combination of welded sand castings and wrought alloys. Aim of the present study is to correlate the monotonic and cyclic deformation behavior of thin sheet welded joints with the microstructure in the heat affected zone of the material combination sand cast EN AC-Al Si7Mg0.3 and wrought alloy EN AW-Al Si1MgMn (EN AW-6082). The metal sheets were welded using a metal inert gas cold metal transfer process under variation of the welding gap, the heat treatment parameters, as well as the surface finishes. It was demonstrated by Wöhler diagrams based on bending fatigue tests that the fatigue life could be increased for the welded and heat treated specimens as compared to the as-received cast specimens. By means of optical microscopy this effect was attributed to microstructural changes due to the optimized welding and heat treatment process. A detailed analysis of the mechanical tests was possible by the application of an optical 3D strain analysis.