The authors thank Dr. U. Deisinger, Institute of Glass and Ceramics, University of Erlangen-Nuremberg, for roughness measurements. Shaoyong Cao and Britta Lilge, TU Darmstadt, are acknowledged for manufacturing patterned films.
Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates†
Article first published online: 19 DEC 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Advanced Engineering Materials
Volume 14, Issue 3, pages B38–B44, March 2012
How to Cite
Detsch, R., Guillon, O., Wondraczek, L. and Boccaccini, A. R. (2012), Initial Attatchment of rMSC and MG-63 Cells on Patterned Bioglass® Substrates. Adv. Eng. Mater., 14: B38–B44. doi: 10.1002/adem.201180068
- Issue published online: 5 MAR 2012
- Article first published online: 19 DEC 2011
- Manuscript Accepted: 19 NOV 2011
- Manuscript Received: 14 JUL 2011
A soft lithography technique was used to introduce surface patterns on the surface of sintered bioactive glass substrates. Osteoblast-like MG-63 cells and rat mesenchymal stem cells (rMSC) seeded on micropatterned bioactive glass surfaces showed different behavior with rMSC exhibiting a better initial attachment than MG-63 cells. Both cytoskeleton formation and cell spreading of rMSC were supported by the bioactive surfaces. In addition, the structured surfaces seemed to guide MG-63 cells to a larger extent than rMSC. The in vitro results are important considering the continuous development of bone tissue scaffolds based on silicate bioactive glasses.