A new one batch approach to a fabrication of a biodegradable Ca-alginate film with embedded vitamin E loaded microspheres was demonstrated, which could be used for planar dermal drug delivery. The stable vitamin E microspheres, coated with gum acacia, were produced by ultrasonic treatment of a two-phase liquid system. The microspheres are well dispersed in alginate film without the presence of agglomerates. Surface modification of the microspheres by poly-L-lysine demonstrates the possibility of their future functionalization with various active substances for several biomedical applications. More details can be found in the article by Borodina et. al. on page B123.