The authors very much appreciate financial support received within the framework of the project “Biocompatible Materials and Applications” initiated by the Austrian Institute of Technology GmbH (AIT), and support from the Staub/Kaiser Foundation, Switzerland.
On the Immersion Testing of Degradable Implant Materials in Simulated Body Fluid: Active pH Regulation Using CO2†
Article first published online: 28 JAN 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Advanced Engineering Materials
Volume 15, Issue 6, pages 434–441, June 2013
How to Cite
Schinhammer, M., Hofstetter, J., Wegmann, C., Moszner, F., Löffler, J. F. and Uggowitzer, P. J. (2013), On the Immersion Testing of Degradable Implant Materials in Simulated Body Fluid: Active pH Regulation Using CO2. Adv. Eng. Mater., 15: 434–441. doi: 10.1002/adem.201200218
- Issue published online: 11 JUN 2013
- Article first published online: 28 JAN 2013
- Manuscript Accepted: 19 DEC 2012
- Manuscript Received: 19 JUN 2012
- Biocompatible Materials and Applications
Predictions of in vivo degradation behavior derived from laboratory experiments are of great importance in the development of biodegradable materials. A key issue is the simulation of the physiological conditions found in living organisms. Generally, the testing solution and in particular the pH buffer have a significant influence on the outcome of degradation experiments. This study presents results obtained from immersion tests in SBF buffered with gaseous CO2. The control of the pH value by means of CO2 has the advantage of better reflecting physiological conditions, and allows the carrying out of in vitro experiments which are closer to the in vivo situation.