Interaction with liquids at the ultra-large surface area of nanoporous material enables a high-efficiency energy dissipation system with wide perspective applications [A. Han, et al., Langmuir 2008, 24, 7044]. In this paper, a nanoporous energy dissipation system composed of a mixture of zeolite ZSM-5 and water is established and studied experimentally. Firstly, quasi-static compression experiments are carried out to analyze the pressure–volume curve and reveal the energy dissipation mechanism. Afterwards, a parametric study is conducted to explore the effects of three parameters, the pretreatment temperature of zeolite ZSM-5 (600–1100 °C), mass ratio of ZSM-5 to water (1:5–6:5), and average zeolite particle size (2.145–5.251 µm before heated or 6.104–9.557 µm after heated). Results show that in order to obtain optimum energy absorption performance, the pretreatment temperature of about 1000 °C, and higher ratio of ZSM-5 with larger particle size are desired. With high energy dissipation and reusability, the zeolite-water system with optimal parameters established herein may become an attractive cushioning device.