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These days nanotechnology start-ups are emerging with increasing frequency in almost every country around the globe, indicating that attitudes towards entrepreneurship are undergoing a significant change. Innovation in nanotechnology often springs from ideas birthed in universities yet the mindset of stakeholders towards entrepreneurship in our seats of knowledge is vastly underappreciated. In this article the challenges faced by academics and students are explored when confronted with the collision between fundamental research in the pursuit of knowledge and applied research directed at the creation of inventions, intellectual property, companies, jobs, products and wealth. For details see the article by Ozin et al. on page 8.