Medical Potentialities of Biomimetic Apatites through Adsorption, Ionic Substitution, and Mineral/Organic Associations: Three Illustrative Examples (pages B224–B233)
Ahmed Al-Kattan, Farid Errassifi, Anne-Marie Sautereau, Stephanie Sarda, Pascal Dufour, Allal Barroug, Isabelle Dos Santos, Christele Combes, David Grossin, Christian Rey and Christophe Drouet
Version of Record online: 30 JUL 2010 | DOI: 10.1002/adem.200980084
Biomimetic apatites exhibit exceptional surface and bulk properties. We illustrate these aspects by way of three selected examples of adsorption and ion substitution in view of conveying new functionalities: the adsorption of risedronate ions on apatite is examined in relation with osteoporosis treatment, the substitution in apatite of some Ca2+ ions by Eu3+ is followed for exploring by FRET the apatite/collagen interface in biocomposites, and the possibility to control apatite agglomeration by surface functionalization with a phospholipid moiety is shown. Such results enable to foresee promising bio-medical applications, even beyond bone-related applications.