Enhanced Bone Cells Growth and Proliferation on TiO2 Nanotubular Substrates Treated by RF Plasma Discharge (pages B95–B101)
Meena Mahmood, Philip Fejleh, Alokita Karmakar, Ashley Fejleh, Yang Xu, Ganesh Kannarpady, Hidetaka Ishihara, Rajesh Sharma, Zhongrui Li, Anindya Ghosh, Steve Trigwell, Franklin D. Hardcastle, Daniel Casciano, Guna Selvaduray and Alexandru S. Biris
Version of Record online: 11 NOV 2010 | DOI: 10.1002/adem.201080072
Vertical and ordered nanotubular TiO2arrays were fabricated by electrochemical anodization and were plasma treated under O2, N2, O2+N2, and He gaseous environments and their properties analyzed by various analytical procedures. Plasma treatments were found to significantly improve the proliferation of steoblast bone cells (MC3T3-E1) over the TiO2 nanoarray substrates, with the O2+N2 combination yielding the most significant improvements. These findings may be explained by the interactions between the cells and the changes in the surface chemistry induced by the O2 and N2 groups introduced by the plasma discharge treatment onto the TiO2 surfaces.