Design of Plasma Surface-Activated, Electrospun Polylactide Non-Wovens with Improved Cell Acceptance (pages B165–B171)
Ralf Wyrwa, Birgit Finke, Henrike Rebl, Nicole Mischner, Marion Quaas, Jan Schaefer, Claudia Bergemann, J. Barbara Nebe, Karsten Schroeder, Klaus-Dieter Weltmann and Matthias Schnabelrauch
Article first published online: 24 FEB 2011 | DOI: 10.1002/adem.201080116
Electrospun poly(L-lactide-co-D,L-lactide) non-wovens are modified with an ultrathin plasma-polymerized allylamine (PPAAm) coating containing positively charged amino groups. The fiber structure of the non-woven is not affected by the plasma treatment and due to the PPAAm-coating the hydrophobic nature of the polymeric non-woven is changed into a hydrophilic one. Cell experiments in vitro demonstrate that the PPAAm-coated surface promotes occupancy of the non-woven by human osteoblasts accompanied by enhanced initial cell spreading and filopodia formation along and between the fibers. Overall, plasma-assisted incorporation of amino groups into non-wovens represents a promising approach to tissue engineering scaffolds with improved cell-material interfaces.