This work was supported by grants from the Korea Health 21 R&D Project of the Ministry of Health and Welfare (02-PJ3-PG6-EV11–0002) and from the Korea Research Foundation (R08–2004–000–10192–0).
Nanofiber Generation of Gelatin–Hydroxyapatite Biomimetics for Guided Tissue Regeneration†
Article first published online: 31 OCT 2005
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Advanced Functional Materials
Volume 15, Issue 12, pages 1988–1994, December, 2005
How to Cite
Kim, H.-W., Song, J.-H. and Kim, H.-E. (2005), Nanofiber Generation of Gelatin–Hydroxyapatite Biomimetics for Guided Tissue Regeneration. Adv. Funct. Mater., 15: 1988–1994. doi: 10.1002/adfm.200500116
- Issue published online: 24 NOV 2005
- Article first published online: 31 OCT 2005
- Manuscript Accepted: 28 JUL 2005
- Manuscript Received: 30 MAY 2005
- Nanocomposites, polymer–nanoparticle;
The development of biomimetic bone matrices is one of the major goals in the bone-regeneration and tissue-engineering fields. Nanocomposites consisting of a natural polymer and hydroxyapatite (HA) nanocrystals, which mimic the human bone matrix, are thus regarded as promising bone regenerative materials. Herein, we developed a biomimetic nanocomposite with a novel nanofibrous structure by employing an electrospinning (ES) method. The HA precipitate/gelatin matrix nanocomposites are lyophilized and dissolved in an organic solvent, and then electrospun under controlled conditions. With this process, we can successfully generate a continuous fiber with a diameter of the order of hundreds of nanometers. The internal structure of the nanofiber features a typical nanocomposite, i.e., HA nanocrystals well distributed within a gelatin matrix. These nanocomposite fibers improve the bone-derived cellular activity significantly when compared to the pure gelatin equivalent. This method of generating a nanofiber of the biomimetic nanocomposite was effective in producing a biomedical membrane with a composition gradient, which is potentially applicable in the field of guided tissue regeneration (GTR).