Feature Article

Mesoporous Silica Nanoparticles for Drug Delivery and Biosensing Applications†

  1. I. I. Slowing,
  2. B. G. Trewyn,
  3. S. Giri,
  4. V. S.-Y. Lin

Article first published online: 20 APR 2007

DOI: 10.1002/adfm.200601191

Issue

Advanced Functional Materials

Advanced Functional Materials

Volume 17, Issue 8, pages 1225–1236, May, 2007

Additional Information

How to Cite

Slowing, I. I., Trewyn, B. G., Giri, S. and Lin, V. S.-Y. (2007), Mesoporous Silica Nanoparticles for Drug Delivery and Biosensing Applications. Adv. Funct. Mater., 17: 1225–1236. doi: 10.1002/adfm.200601191

Author Information

  1. Department of Chemistry and U.S. DOE Ames Laboratory, Iowa State University, Ames, IA 50011 (USA)

  1. †

    The authors thank the U.S. National Science Foundation (CHE-0239570) and the U.S. DOE Ames Laboratory (W-7405-Eng-82) for their support of the research.

Publication History

  1. Issue published online: 15 MAY 2007
  2. Article first published online: 20 APR 2007
  3. Manuscript Revised: 26 JAN 2007
  4. Manuscript Received: 13 DEC 2006

Funded by

  • U.S. National Science Foundation. Grant Number: CHE-0239570
  • U.S. DOE Ames Laboratory. Grant Number: W-7405-Eng-82

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Keywords:

  • Biosensors;
  • Controlled release;
  • Drug delivery;
  • Mesoporous materials;
  • Nanoparticles

Abstract

Recent advancements in morphology control and surface functionalization of mesoporous silica nanoparticles (MSNs) have enhanced the biocompatibility of these materials with high surface areas and pore volumes. Several recent reports have demonstrated that the MSNs can be efficiently internalized by animal and plant cells. The functionalization of MSNs with organic moieties or other nanostructures brings controlled release and molecular recognition capabilities to these mesoporous materials for drug/gene delivery and sensing applications, respectively. Herein, we review recent research progress on the design of functional MSN materials with various mechanisms of controlled release, along with the ability to achieve zero release in the absence of stimuli, and the introduction of new characteristics to enable the use of nonselective molecules as screens for the construction of highly selective sensor systems.

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