The authors acknowledge the financial support provided by FCT through the POCTI and FEDER programs and POCTI/FIS/61621/2004.
Thermally Responsive Biomineralization on Biodegradable Substrates†
Article first published online: 20 SEP 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Advanced Functional Materials
Volume 17, Issue 16, pages 3312–3318, November, 2007
How to Cite
Shi, J., Alves, N. M. and Mano, J. F. (2007), Thermally Responsive Biomineralization on Biodegradable Substrates. Adv. Funct. Mater., 17: 3312–3318. doi: 10.1002/adfm.200601206
- Issue published online: 29 OCT 2007
- Article first published online: 20 SEP 2007
- Manuscript Revised: 18 APR 2007
- Manuscript Received: 15 DEC 2006
- FCT through the POCTI and FEDER programs. Grant Number: POCTI/FIS/61621/2004
- Polymer composites;
- Stimuli-responsive materials
Biomineralization offers an elegant example of how nature can design complex, hierarchical, and structurally/morphologically controllable materials. In this work, the surface of bioactive substrates prepared from poly(L-lactic acid) and reinforced with Bioglass are modified by the graft polymerization of poly(N-isopropylacrylamide), (PNIPAAm) after plasma activation. It is found that such treatment, together with temperature, could trigger the formation of apatite on the biodegradable substrate upon immersion in simulated body fluid above the PNIPAAm lower critical solution temperature (LCST); in contrast, no apatite is formed at room temperature. A control experiment on a material that is not subjected to surface treatment does not show any evidence of mineral deposition at the two analyzed temperatures. This “smart” biomineralization concept is combined with patterning methodologies to control the microstructure of the surface onto which PNIPAAm is grafted. In this case, the apatite is formed at 37 °C in the modified regions. We suggest that this concept could be extended in the biomimetic production of other minerals, where it would be triggered by another kind of stimulus (e.g., pH or ionic strength) in substrates with more complex geometries.