S.D.K. thanks the Stichting Emmanuel van der Schueren (Vlaamse Liga tegen Kanker) for funding this research. B.G.D.G. thanks TiPharma for a postdoctoral fellowship. Supporting Information is available online from Wiley InterScience or from the authors.
In vivo Cellular Uptake, Degradation, and Biocompatibility of Polyelectrolyte Microcapsules†
Article first published online: 28 NOV 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Advanced Functional Materials
Volume 17, Issue 18, pages 3754–3763, December, 2007
How to Cite
De Koker, S., De Geest, B. G., Cuvelier, C., Ferdinande, L., Deckers, W., Hennink, W. E., De Smedt, S. C. and Mertens, N. (2007), In vivo Cellular Uptake, Degradation, and Biocompatibility of Polyelectrolyte Microcapsules. Adv. Funct. Mater., 17: 3754–3763. doi: 10.1002/adfm.200700416
- Issue published online: 6 DEC 2007
- Article first published online: 28 NOV 2007
- Manuscript Revised: 14 AUG 2007
- Manuscript Received: 12 APR 2007
- Stichting Emmanuel van der Schueren
- Biocompatible materials;
- Biomedical materials;
Polyelectrolyte microcapsules are made by layer-by-layer (LbL) coating of a sacrificial template, followed by decomposition of the template, to produce hollow microcapsules. In this paper, we report on the in vivo cellular uptake, degradation and biocompatibility of polyelectrolyte microcapsules produced from alternating dextran sulphate and poly-L-arginine layers on a template of calcium carbonate microparticles. We show that a moderate tissue reaction is observed after subcutaneous injection of polyelectrolyte microcapsules in mice. Within sixteen days after subcutaneous injection, most of the microcapsules are internalized by the cells and start to get degraded. The number of polyelectrolyte layers determines the stability of the microcapsules after cellular uptake.