Drs. M. A. Roberts and A. Lennie are thanked for their help in using the 9.1 diffractometer at the SRS (CCLRC, UK). Prof. Alex Hannon is thanked for his help in using GEM at ISIS (CCLRC, UK). VF thanks the EPSRC and the University of Kent for her studentship.
A Neutron and X-Ray Diffraction Study of Bioglass® with Reverse Monte Carlo Modelling†
Article first published online: 28 NOV 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Advanced Functional Materials
Volume 17, Issue 18, pages 3746–3753, December, 2007
How to Cite
FitzGerald, V., Pickup, D. M., Greenspan, D., Sarkar, G., Fitzgerald, J. J., Wetherall, K. M., Moss, R. M., Jones, J. R. and Newport, R. J. (2007), A Neutron and X-Ray Diffraction Study of Bioglass® with Reverse Monte Carlo Modelling. Adv. Funct. Mater., 17: 3746–3753. doi: 10.1002/adfm.200700433
- Issue published online: 6 DEC 2007
- Article first published online: 28 NOV 2007
- Manuscript Revised: 28 AUG 2007
- Manuscript Received: 16 APR 2007
- Biomedical applications;
A class of melt-quenched silicate glasses, containing calcium, phosphorus and alkali metals, and having the ability to promote bone regeneration and to fuse to living bone, creating strong implants with less danger of interfacial instability than previous materials, is produced commercially as Bioglass® and sold under the brand names of PerioGlas®, NovaBone® and NovaBone-C/M®. We have collected the first high energy X-ray and neutron diffraction data, on this important material in the hope of providing more direct experimental insight into the glass structure. Similarly, the first solid state MAS (magic angle spinning) 29Si, 31P, and 23Na NMR data on the material is presented. The diffraction data has been modeled using the reverse Monte Carlo (RMC) method to allow the identification of the atomic-scale structural features present; the solid state NMR data is used explicitly within the model-building process as a constraint on the connectivity of the network. The 29Si NMR suggests that the host silica network primarily consists of chains and rings of Q2 SiO4 tetrahedra, with some degree of cross linking as represented by the presence of Q3 units. The diffraction-based RMC model suggests a Na–O distance of 2.35 Å and a corresponding coordination of ∼ 6; the coordination number is supported by the 23Na NMR data presented here which reveals that the likely sodium environment is six-coordinate in pseudo-octahedral arrangement. The RMC model provides evidence for the non-uniform distribution of Ca, which is in line with previous molecular dynamics simulation results, and the data is also suggestive of CaO as the associated structural motif within the high calcium content regions of the glass.