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A Triantennary Dendritic Galactoside-Capped Nanohybrid with a ZnS/CdSe Nanoparticle Core as a Hydrophilic, Fluorescent, Multivalent Probe for Metastatic Lung Cancer Cells†

  1. Chien-Tien Chen1,*,
  2. Yogesh S. Munot1,
  3. Santosh B. Salunke1,
  4. Yi-Ching Wang3,*,
  5. Ruo-Kai Lin2,
  6. Chun-Cheng Lin4,
  7. Chia-Chun Chen1,
  8. Y-Hasin Liu1

Article first published online: 28 FEB 2008

DOI: 10.1002/adfm.200700449

Issue

Advanced Functional Materials

Advanced Functional Materials

Volume 18, Issue 4, pages 527–540, February 22, 2008

Additional Information

How to Cite

Chen, C.-T., Munot, Y. S., Salunke, S. B., Wang, Y.-C., Lin, R.-K., Lin, C.-C., Chen, C.-C. and Liu, Y.-H. (2008), A Triantennary Dendritic Galactoside-Capped Nanohybrid with a ZnS/CdSe Nanoparticle Core as a Hydrophilic, Fluorescent, Multivalent Probe for Metastatic Lung Cancer Cells. Adv. Funct. Mater., 18: 527–540. doi: 10.1002/adfm.200700449

Author Information

  1. 1

    Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan; #88, Sec. 4 Ding-jou Road, Taipei 11650 (Taiwan)

  2. 2

    Department of Biosciences, National Taiwan Normal University Taipei, Taiwan; #88, Sec. 4 Ding-jou Road, Taipei 11650 (Taiwan)

  3. 3

    Department of Pharmacology, College of Medicine, National Cheng Kung University (Taiwan)

  4. 4

    Department of Chemistry, National Tsing-Hua University Hsin-chu (Taiwan)

*Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan; #88, Sec. 4 Ding-jou Road, Taipei 11650 (Taiwan).

  1. †

    We thank the National Science Council of the Republic of China for a generous financial support of this research. Supporting Information is available online from Wiley InterScience or from the authors.

Publication History

  1. Issue published online: 28 FEB 2008
  2. Article first published online: 28 FEB 2008
  3. Manuscript Revised: 3 JUL 2007
  4. Manuscript Received: 19 APR 2007

Funded by

  • National Science Council of the Republic of China

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Keywords:

  • Receptor-mediated;
  • Endocytotic;
  • Triantemmary-galactose nanohybrids;
  • Click chemistry;
  • Multivalency binding

Abstract

A new tri-antennary, galactoside-capped gallamide dendritic anchor with thiolate focal group is synthesized via click chemistry. The highly hydrophilic dendron was efficiently anchored onto the surface of CdSe/ZnS core/shell nanoparticles in a covalent fashion, as evidenced by 1H NMR spectrum of the resultant nanohybrid with intact core fluorescent property. The water-soluble nano-hybrid was found smoothly and selectively uptaken by lung cancer cells enriched with membrane-bound asialoprotein receptors in 2–3 h, as evidenced by confocal microscopic analysis. Furthermore, cancer cells that are undergoing active mitosis also tend to uptake the nanohybrids efficiently and remain sustainable in serum-containing medium for several days, which shed light on its application as a photodynamic drug carrier for apoptosis study.

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