This study was supported by the Analysis and Testing Foundation of Northeast Normal University and the National Natural Science Foundation of China (No. 20703009).
Monodispersed Gold Nanorod-Embedded Silica Particles as Novel Raman Labels for Biosensing†
Article first published online: 29 JAN 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Advanced Functional Materials
Volume 18, Issue 2, pages 355–361, January, 2008
How to Cite
Wang, C., Chen, Y., Wang, T., Ma, Z. and Su, Z. (2008), Monodispersed Gold Nanorod-Embedded Silica Particles as Novel Raman Labels for Biosensing. Adv. Funct. Mater., 18: 355–361. doi: 10.1002/adfm.200700503
- Issue published online: 29 JAN 2008
- Article first published online: 29 JAN 2008
- Manuscript Revised: 19 OCT 2007
- Manuscript Received: 4 MAY 2007
- Analysis and Testing Foundation of Northeast Normal University and the National Natural Science Foundation of China. Grant Number: 20703009
- Surface-enhanced Raman spectroscopy
Biocompatible, photostable, and multiplexing-compatible surface-enhanced Raman spectroscopic tagging materials have been developed that are composed of gold nanorod (GNR)-embedded silica particles and organic Raman labels. GNR-embedded silica particles were prepared with different surface coverage by the assembly of GNRs on silica particles based on an electrostatic interaction and subsequent coating of silica with controllable thickness. This method allows the incorporation of various organic Raman labels to generate intense surface-enhanced Raman scattering (SERS) spectra. Furthermore, SERS-active particles are demonstrated as novel Raman tags for immunoassay. The results suggest SERS tags can be used for multiplex and ultrasensitive detection of biomolecules.