Polymer Microcapsules with Carbohydrate-Sensitive Properties

Authors

  • Tatjana Levy,

    Corresponding author
    1. Max Planck Institute of Colloids and Interfaces Wissenschaftspark Golm, 14424 Potsdam (Germany)
    2. Present address: BASF AG, Carl-Bosch-Str. 64, 67117 Limburgerhof, Germany.
    • Max Planck Institute of Colloids and Interfaces Wissenschaftspark Golm, 14424 Potsdam (Germany).
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  • Christophe Déjugnat,

    1. Max Planck Institute of Colloids and Interfaces Wissenschaftspark Golm, 14424 Potsdam (Germany)
    2. Institut de Chimie Séparative de Marcoule UMR 5257, CEA Valrhô, 30207 Bagnols-sur-Cèze Cedex (France)
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  • Gleb B. Sukhorukov

    1. Department of Materials, Queen Mary University of London Mile End Road, E1 4NS, London (UK)
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  • The authors thank Prof. H. Möhwald for his continuous support and stimulating discussions. A. Heilig is thanked for atomic force microscopy measurements. This work was supported by the 6th FP EU-project STREP001 428 “Nanocapsules for Targeted Controlled Delivery of Chemicals”.

Abstract

Carbohydrate-sensitive polymer multilayers are assembled onto flat substrates and colloidal CaCO3 particles via reversible covalent ester formation between the polysaccharide mannan and phenylboronic acid moieties grafted onto poly(acrylic acid) (PAA). The resulting multilayer films are sensitive to several carbohydrates, and show the highest sensitivity to fructose. The response to carbohydrates arises from the competitive binding of small molecular weight sugars and mannan to boronic acid groups within the films, and is observed as a rapid dissolution of the multilayers upon contact with a sugar-containing solution above a critical concentration. In addition, carbohydrate-sensitive multilayer capsules are prepared, and their sugar-dependent stability is investigated by following the release of encapsulated tetramethylrhodamine isothiocyanate-bovine serum albumin (TRITC-BSA).

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