Uniform Rattle-type Hollow Magnetic Mesoporous Spheres as Drug Delivery Carriers and their Sustained-Release Property

Authors

  • Wenru Zhao,

    1. Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering East China University of Science and Technology, Shanghai 200237 (P. R. China)
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  • Hangrong Chen,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai 200050 (P. R. China)
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  • Yongsheng Li,

    1. Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering East China University of Science and Technology, Shanghai 200237 (P. R. China)
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  • Liang Li,

    1. Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering East China University of Science and Technology, Shanghai 200237 (P. R. China)
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  • Meidong Lang,

    1. Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering East China University of Science and Technology, Shanghai 200237 (P. R. China)
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  • Jianlin Shi

    Corresponding author
    1. Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering East China University of Science and Technology, Shanghai 200237 (P. R. China)
    2. State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai 200050 (P. R. China)
    • Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering East China University of Science and Technology, Shanghai 200237 (P. R. China).
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  • The authors gratefully acknowledge the support of the Shanghai Nano-Science Program (Grant No. 0652 nm014), the National Natural Science Foundation of China (Grant No. 20571081), the National Hi-Tech Project of China (Grant No. 2007AA03Z317), the Chinese Academy of Sciences (Grant No. KJCX2.YW.M02), and the China Postdoctoral Science Foundation (Grant No. 20070410697).

Abstract

A novel kind of rattle-type hollow magnetic mesoporous sphere (HMMS) with Fe3O4 particles encapsulated in the cores of mesoporous silica microspheres has been successfully fabricated by sol–gel reactions on hematite particles followed by cavity generation with hydrothermal treatment and H2 reduction. Such a structure has the merits of both enhanced drug-loading capacity and a significant magnetization strength. The prepared HMMSs realize a relatively high storage capacity up to 302 mg g−1 when ibuprofen is used as a model drug, and the IBU–HMMS system has a sustained-release property, which follows a Fick's law.

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