We thank Dr. Antonietta Rizzo for help. This work was carried out with support from the EU-STRP 0032352 BIODOT project. Partial support by the DFG Nanosystems Initiative Munich (NIM) is also acknowledged. Supporting Information is available online from Wiley InterScience or from the author.
Neural Networks Grown on Organic Semiconductors†
Article first published online: 12 JUN 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Advanced Functional Materials
Volume 18, Issue 12, pages 1751–1756, June 24, 2008
How to Cite
Bystrenova, E., Jelitai, M., Tonazzini, I., N. Lazar, A., Huth, M., Stoliar, P., Dionigi, C., Cacace, M. G., Nickel, B., Madarasz, E. and Biscarini, F. (2008), Neural Networks Grown on Organic Semiconductors. Adv. Funct. Mater., 18: 1751–1756. doi: 10.1002/adfm.200701350
- Issue published online: 18 JUN 2008
- Article first published online: 12 JUN 2008
- Manuscript Revised: 13 MAR 2008
- Manuscript Received: 11 NOV 2007
- Thin films;
- Biological interfaces
We report adhesion, growth, and differentiation of mouse neural cells on ultra-thin films of an organic semiconductor, pentacene. We demonstrate that i) pentacene is structurally and morphologically stable upon prolonged contact with water, physiological buffer, and cell culture medium; ii) neural stem cells adhere to pentacene and remain viable on it for at least 15 days; iii) densely interconnected neural networks and glial cells develop on the pentacene surface after several days. This implies that adhesion proteins secreted by the cells find suitable adsorption loci to anchor the cells. Pentacene is also a suitable substrate for casting thin layers of cell adhesion molecules, such as laminin and poly-L-lysine. Our results show that pentacene, albeit being an aromatic molecule, allows neurons to adhere to and grow on it, which is possibly due to its tightly packed solid state structure. This structure remains unaltered upon exposure to water and interfacial force exerted by the cells. The integration of living cells into organic semiconductors is an important step towards the development of bio-organic electronic transducers of cellular signals from neural networks.