Designed Fabrication of Silica-Based Nanostructured Particle Systems for Nanomedicine Applications

Authors

  • Yuanzhe Piao,

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering Seoul National University, Seoul 151-744 (Korea)
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  • Andrew Burns,

    1. Department of Materials Science and Engineering, Cornell University Ithaca, NY 14853 (USA)
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  • Jaeyun Kim,

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering Seoul National University, Seoul 151-744 (Korea)
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  • Ulrich Wiesner,

    Corresponding author
    1. Department of Materials Science and Engineering, Cornell University Ithaca, NY 14853 (USA)
    • Department of Materials Science and Engineering, Cornell University Ithaca, NY 14853 (USA).
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  • Taeghwan Hyeon

    Corresponding author
    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering Seoul National University, Seoul 151-744 (Korea)
    • National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering Seoul National University, Seoul 151-744 (Korea).
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  • T. H. acknowledges financial support by the Korean Ministry of Education, Science and Technology through the National Creative Research Initiative Program of the Korea Science and Engineering Foundation (KOSEF). A. B. and U. W. would like to thank the Cornell Center for Materials Research, a MRSEC Center funded by the NSF (Grant DMR 0520404) and the Cornell Nanobiotechnology Center, and STC Program of the National Science Foundation under Agreement No. ECS-9876771, for funding and infrastructure.

Abstract

Suitably integrating multiple nanomaterials into nanostructured particle systems with specific combinations of properties has recently attracted significant attention in the research community. In particular, numerous particle systems have been designed and fabricated by integrating diverse materials with monodispersed silica nanoparticles. One or more distinct nanomaterials can be assembled on, encapsulated within, or integrated both inside and on the surface of silica nanoparticles using different chemistries and techniques to create multifunctional nanosystems. Research on these particle systems for biomedical applications has progressed rapidly during recent years due to the synergistic advantages of these complexes compared to the use of single components. This feature article surveys recent research progress on the fabrication strategies of these nanoparticle systems and their applications to medical diagnostics and therapy, thereby paving the way for the emerging field of nanomedicine.

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