Feature Article

Designed Fabrication of Silica-Based Nanostructured Particle Systems for Nanomedicine Applications†

  1. Yuanzhe Piao1,
  2. Andrew Burns2,
  3. Jaeyun Kim1,
  4. Ulrich Wiesner2,*,
  5. Taeghwan Hyeon1,*

Article first published online: 22 SEP 2008

DOI: 10.1002/adfm.200800731

Issue

Advanced Functional Materials

Advanced Functional Materials

Special Issue: International Conference on Nanoscience and Nanotechnology 2008

Volume 18, Issue 23, pages 3745–3758, December 8, 2008

Additional Information

How to Cite

Piao, Y., Burns, A., Kim, J., Wiesner, U. and Hyeon, T. (2008), Designed Fabrication of Silica-Based Nanostructured Particle Systems for Nanomedicine Applications. Adv. Funct. Mater., 18: 3745–3758. doi: 10.1002/adfm.200800731

Author Information

  1. 1

    National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering Seoul National University, Seoul 151-744 (Korea)

  2. 2

    Department of Materials Science and Engineering, Cornell University Ithaca, NY 14853 (USA)

*Department of Materials Science and Engineering, Cornell University Ithaca, NY 14853 (USA).

  1. †

    T. H. acknowledges financial support by the Korean Ministry of Education, Science and Technology through the National Creative Research Initiative Program of the Korea Science and Engineering Foundation (KOSEF). A. B. and U. W. would like to thank the Cornell Center for Materials Research, a MRSEC Center funded by the NSF (Grant DMR 0520404) and the Cornell Nanobiotechnology Center, and STC Program of the National Science Foundation under Agreement No. ECS-9876771, for funding and infrastructure.

Publication History

  1. Issue published online: 2 DEC 2008
  2. Article first published online: 22 SEP 2008
  3. Manuscript Received: 28 MAY 2008

Funded by

  • Korean Ministry of Education, Science and Technology
  • NSF. Grant Number: DMR 0520404
  • Cornell Nanobiotechnology Center
  • STC Program of the National Science Foundation. Grant Number: ECS-9876771

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (943K)

Keywords:

  • diagnostics;
  • nanomedicine;
  • silica nanoparticles;
  • therapy

Abstract

Suitably integrating multiple nanomaterials into nanostructured particle systems with specific combinations of properties has recently attracted significant attention in the research community. In particular, numerous particle systems have been designed and fabricated by integrating diverse materials with monodispersed silica nanoparticles. One or more distinct nanomaterials can be assembled on, encapsulated within, or integrated both inside and on the surface of silica nanoparticles using different chemistries and techniques to create multifunctional nanosystems. Research on these particle systems for biomedical applications has progressed rapidly during recent years due to the synergistic advantages of these complexes compared to the use of single components. This feature article surveys recent research progress on the fabrication strategies of these nanoparticle systems and their applications to medical diagnostics and therapy, thereby paving the way for the emerging field of nanomedicine.

Get PDF (943K)