Novel Brush Polymers with Phosphorylcholine Bristle Ends: Synthesis, Structure, Properties, and Biocompatibility

Authors

  • Gahee Kim,

    1. Department of Chemistry National Research Lab for Polymer Synthesis and Physics Pohang Accelerator Laboratory Center for Electro-Photo Behaviors in Advanced Molecular Systems Polymer Research Institute Graduate Institute of Advanced Materials Science and BK School of Molecular Science Pohang University of Science and Technology Pohang 790-784 (Republic of Korea)
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  • Samdae Park,

    1. Department of Chemistry National Research Lab for Polymer Synthesis and Physics Pohang Accelerator Laboratory Center for Electro-Photo Behaviors in Advanced Molecular Systems Polymer Research Institute Graduate Institute of Advanced Materials Science and BK School of Molecular Science Pohang University of Science and Technology Pohang 790-784 (Republic of Korea)
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  • Jungwoon Jung,

    1. Department of Chemistry National Research Lab for Polymer Synthesis and Physics Pohang Accelerator Laboratory Center for Electro-Photo Behaviors in Advanced Molecular Systems Polymer Research Institute Graduate Institute of Advanced Materials Science and BK School of Molecular Science Pohang University of Science and Technology Pohang 790-784 (Republic of Korea)
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  • Kyuyoung Heo,

    1. Department of Chemistry National Research Lab for Polymer Synthesis and Physics Pohang Accelerator Laboratory Center for Electro-Photo Behaviors in Advanced Molecular Systems Polymer Research Institute Graduate Institute of Advanced Materials Science and BK School of Molecular Science Pohang University of Science and Technology Pohang 790-784 (Republic of Korea)
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  • Jinhwan Yoon,

    1. Department of Chemistry National Research Lab for Polymer Synthesis and Physics Pohang Accelerator Laboratory Center for Electro-Photo Behaviors in Advanced Molecular Systems Polymer Research Institute Graduate Institute of Advanced Materials Science and BK School of Molecular Science Pohang University of Science and Technology Pohang 790-784 (Republic of Korea)
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  • Heesoo Kim,

    Corresponding author
    1. Department of Microbiology and Dongguk Medical Institute Dongguk University College of Medicine Gyeongju 780-714 (Republic of Korea)
    • Department of Microbiology and Dongguk Medical Institute Dongguk University College of Medicine Gyeongju 780-714 (Republic of Korea).
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  • Ik Jung Kim,

    1. Department of Microbiology and Dongguk Medical Institute Dongguk University College of Medicine Gyeongju 780-714 (Republic of Korea)
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  • Jung Ran Kim,

    1. Department of Pathology and Dongguk Medical Institute Dongguk University College of Medicine Gyeongju 780-714 (Republic of Korea)
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  • Jong Im Lee,

    1. Department of Pathology and Dongguk Medical Institute Dongguk University College of Medicine Gyeongju 780-714 (Republic of Korea)
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  • Moonhor Ree

    Corresponding author
    1. Department of Chemistry National Research Lab for Polymer Synthesis and Physics Pohang Accelerator Laboratory Center for Electro-Photo Behaviors in Advanced Molecular Systems Polymer Research Institute Graduate Institute of Advanced Materials Science and BK School of Molecular Science Pohang University of Science and Technology Pohang 790-784 (Republic of Korea)
    • Department of Chemistry National Research Lab for Polymer Synthesis and Physics Pohang Accelerator Laboratory Center for Electro-Photo Behaviors in Advanced Molecular Systems Polymer Research Institute Graduate Institute of Advanced Materials Science and BK School of Molecular Science Pohang University of Science and Technology Pohang 790-784 (Republic of Korea).
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Abstract

New brush polymers with various numbers of bristle ends incorporating phosphorylcholine (PC) moieties are synthesized. The polymers are thermally stable up to 175 °C and form good-quality films with conventional spin-, roll-, and dip-coating, and subsequent drying processes. Interestingly, all these brush polymers, as a PC-containing polymer, demonstrate a stable molecular multi-bilayer structure in thin films that arise due to the efficient self-assembly of the bristles for temperatures <55 °C and PC-rich surfaces, and therefore successfully mimic natural cell-membrane surfaces. These brush-polymer films exhibit excellent water wettability and water sorption whilst retaining the remarkable molecular multi-bilayer structure, and thus have hydrophilic surfaces. These novel multi-bilayer structured films repel fibrinogen molecules and platelets from their surfaces but also have bactericidal effects on bacteria. Moreover, the brush-polymer films are found to provide comfortable surface environments for the successful anchoring and growth of HEp-2 cells, and to exhibit excellent biocompatibility in mice. These newly developed brush polymers are suitable for use in biomedical applications including medical devices and biosensors that require biocompatibility and the reduced possibility of post-operative infection.

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