• dendrimers;
  • drug delivery;
  • nanoparticles
Thumbnail image of graphical abstract

Highly branched, biodegradable, biocompatible macromolecular systems were developed by surface engineering poly(amidoamine) dendrimer nanoparticles with a water-soluble chitosan derivative, as reported by Joaquim M. Oliveira and co-workers on p. 1840. These structures were organized into sphere-like nanoparticles that have the potential to be used as intracellular drug-delivery carriers for a wide range of applications that require efficient intracellular delivery of biological agents tomodulate the behavior of stem cells, for example, their proliferation and differentiation. These applications might include the use of differentiation factors to act within cells (see cover) or genetic material.