Cover Picture: Surface Engineered Carboxymethylchitosan/Poly(amidoamine) Dendrimer Nanoparticles for Intracellular Targeting (Adv. Funct. Mater. 12/2008)

Authors

  • Joaquim M. Oliveira,

    1. 3B's Research Group—Biomaterials, Biodegradables and Biomimetics IBB—Institute for Biotechnology and Bioengineering PT Government Associated Laboratory Department of Polymer Engineering University of Minho, Campus Gualtar, 4710-057 Braga (Portugal)
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  • Noriko Kotobuki,

    1. Research Institute for Cell Engineering (RICE) National Institute of Advanced Industrial Science and Technology (AIST) Nakoji 3-11-46, Amagasaki, Hyogo 661-0974 (Japan)
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  • Alexandra P. Marques,

    1. 3B's Research Group—Biomaterials, Biodegradables and Biomimetics IBB—Institute for Biotechnology and Bioengineering PT Government Associated Laboratory Department of Polymer Engineering University of Minho, Campus Gualtar, 4710-057 Braga (Portugal)
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  • Rogério P. Pirraco,

    1. 3B's Research Group—Biomaterials, Biodegradables and Biomimetics IBB—Institute for Biotechnology and Bioengineering PT Government Associated Laboratory Department of Polymer Engineering University of Minho, Campus Gualtar, 4710-057 Braga (Portugal)
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  • Johan Benesch,

    1. 3B's Research Group—Biomaterials, Biodegradables and Biomimetics IBB—Institute for Biotechnology and Bioengineering PT Government Associated Laboratory Department of Polymer Engineering University of Minho, Campus Gualtar, 4710-057 Braga (Portugal)
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  • Motohiro Hirose,

    1. Research Institute for Cell Engineering (RICE) National Institute of Advanced Industrial Science and Technology (AIST) Nakoji 3-11-46, Amagasaki, Hyogo 661-0974 (Japan)
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  • Silgia A. Costa,

    1. 3B's Research Group—Biomaterials, Biodegradables and Biomimetics IBB—Institute for Biotechnology and Bioengineering PT Government Associated Laboratory Department of Polymer Engineering University of Minho, Campus Gualtar, 4710-057 Braga (Portugal)
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  • João F. Mano,

    1. 3B's Research Group—Biomaterials, Biodegradables and Biomimetics IBB—Institute for Biotechnology and Bioengineering PT Government Associated Laboratory Department of Polymer Engineering University of Minho, Campus Gualtar, 4710-057 Braga (Portugal)
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  • Hajime Ohgushi,

    1. Research Institute for Cell Engineering (RICE) National Institute of Advanced Industrial Science and Technology (AIST) Nakoji 3-11-46, Amagasaki, Hyogo 661-0974 (Japan)
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  • Rui L. Reis

    Corresponding author
    1. 3B's Research Group—Biomaterials, Biodegradables and Biomimetics IBB—Institute for Biotechnology and Bioengineering PT Government Associated Laboratory Department of Polymer Engineering University of Minho, Campus Gualtar, 4710-057 Braga (Portugal)
    • 3B's Research Group—Biomaterials, Biodegradables and Biomimetics IBB—Institute for Biotechnology and Bioengineering PT Government Associated Laboratory Department of Polymer Engineering University of Minho, Campus Gualtar, 4710-057 Braga (Portugal).
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Abstract

original image

Highly branched, biodegradable, biocompatible macromolecular systems were developed by surface engineering poly(amidoamine) dendrimer nanoparticles with a water-soluble chitosan derivative, as reported by Joaquim M. Oliveira and co-workers on p. 1840. These structures were organized into sphere-like nanoparticles that have the potential to be used as intracellular drug-delivery carriers for a wide range of applications that require efficient intracellular delivery of biological agents tomodulate the behavior of stem cells, for example, their proliferation and differentiation. These applications might include the use of differentiation factors to act within cells (see cover) or genetic material.

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