Advances and Applications of Biodegradable Elastomers in Regenerative Medicine

Authors

  • Maria Concepcion Serrano,

    1. Biomedical Engineering Department E310 Technological Institute Northwestern University Evanston, IL 60208 (USA)
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  • Eun Ji Chung,

    1. Biomedical Engineering Department E310 Technological Institute Northwestern University Evanston, IL 60208 (USA)
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  • Guillermo. A. Ameer

    Corresponding author
    1. Biomedical Engineering Department E310 Technological Institute Northwestern University Evanston, IL 60208 (USA)
    2. Feinberg School of Medicine Division of Vascular Surgery Department of Surgery Northwestern University Chicago, IL 60611 (USA)
    3. Institute of Bionanotechnology in Medicine Northwestern University Chicago, IL 60611 (USA)
    • Biomedical Engineering Department E310 Technological Institute Northwestern University Evanston, IL 60208 (USA)
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Abstract

When elastomers were first proposed as useful materials for regenerative medicine a few decades ago, their high versatility and suitability for a diverse and wide range of in vivo applications could not have been predicted. Due to their ability to recover after deformation, these materials were first introduced in tissue engineering in an attempt to mimic the mechanical properties of the extracellular matrix. Furthermore, elastomeric characteristics have been described as important criteria for cell interaction by modulating cellular behavior. From soft to hard tissues, elastomers have demonstrated degradation, mechanical, and biocompatibility requirements in accordance with the target tissue. In this feature article, biodegradable synthetic polyester elastomers that have been reported in the literature are discussed, with special focus on those that show promise for in vivo tissue replacement. Their satisfactory performance in vivo shows the promise of elastomers for use in regenerative medicine. However, further investigation is required to demonstrate the prospect of elastomer-based therapies in clinical trials.

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