Surface Modification of Exfoliated Layered Gadolinium Hydroxide for the Development of Multimodal Contrast Agents for MRI and Fluorescence Imaging

Authors

  • Young-su Yoon,

    1. Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea)
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  • Byung-Il Lee,

    1. Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea)
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  • Kyung Sig Lee,

    1. Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea)
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  • Geun Ho Im,

    1. Department of Radiology, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 (Korea)
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  • Song-Ho Byeon,

    Corresponding author
    1. Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea)
    • Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea).
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  • Jung Hee Lee,

    Corresponding author
    1. Department of Radiology, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 (Korea)
    • Department of Radiology, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 (Korea)
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  • In Su Lee

    Corresponding author
    1. Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea)
    • Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea).
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Abstract

A novel method for modifying the surface of magnetic-resonance-contrasting layered gadolinium hydroxide (LGdH) is developed providing them with water- and bio-compatibility and acid-resistance, all of which are essential for medical applications. A stable colloid of exfoliated layers is synthesized by exchanging interlayer anions of LGdH with oleate ions. The delaminated layers are successively coated with phospholipids with poly(ethylene glycol) tail groups, and their effectiveness as a contrast agent for magnetic resonance imaging (MRI) is demonstrated. The adaptability of this surface modification approach for incorporating functional molecules and fabricating a fluorescent colloid of LGdH, which has the potential utility as a multimodal probe, is also demonstrated. This result provides a novel approach for expanding the applications of layered inorganic materials and developing a new class of MRI contrast agents.

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