Dual Stimuli-Responsive Supramolecular Polypeptide-Based Hydrogel and Reverse Micellar Hydrogel Mediated by Host–Guest Chemistry

Authors

  • Yi Chen,

    1. Department of Polymer Science and Engineering School of Chemistry and Chemical Engineering Shanghai Jiao Tong University, Shanghai 200240 (P. R. China)
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  • Xiao-Hui Pang,

    1. Department of Polymer Science and Engineering School of Chemistry and Chemical Engineering Shanghai Jiao Tong University, Shanghai 200240 (P. R. China)
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  • Chang-Ming Dong

    Corresponding author
    1. Department of Polymer Science and Engineering School of Chemistry and Chemical Engineering Shanghai Jiao Tong University, Shanghai 200240 (P. R. China)
    • Department of Polymer Science and Engineering School of Chemistry and Chemical Engineering Shanghai Jiao Tong University, Shanghai 200240 (P. R. China).
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Abstract

Versatile strategies are currently being discovered for the fabrication of synthetic polypeptide-based hybrid hydrogels, which have potential applications in polymer therapeutics and regenerative medicine. Herein, a new concept—the reverse micellar hydrogel—is introduced, and a versatile strategy is provided for fabricating supramolecular polypeptide-based normal micellar hydrogel and reverse micellar hydrogels from the same polypeptide-based copolymer via the cooperation of host–guest chemistry and hydrogen-bonding interactions. The supramolecular hydrogels are thoroughly characterized, and a mechanism for their self-assembly is proposed. These hydrogels can respond to dual stimuli—temperature and pH—and their mechanical and controlled drug-release properties can be tuned by the copolymer topology and the polypeptide composition. The reverse micellar hydrogel can load 10% of the anticancer drug doxorubicin hydrochloride (DOX) and sustain DOX release for 45 days, indicating that it could be useful as an injectable drug delivery system.

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