Get access

Preparation of Uniform, Water-Soluble, and Multifunctional Nanocomposites with Tunable Sizes

Authors

  • Dechao Niu,

    1. Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 (China)
    Search for more papers by this author
  • Yongsheng Li,

    Corresponding author
    1. Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 (China)
    • Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 (China).
    Search for more papers by this author
  • Zhi Ma,

    1. Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 (China)
    Search for more papers by this author
  • Hua Diao,

    1. Shanghai Institute of Planned Parenthood Research Shanghai 200032 (China)
    Search for more papers by this author
  • Jinlou Gu,

    1. Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 (China)
    Search for more papers by this author
  • Hangrong Chen,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 (China)
    Search for more papers by this author
  • Wenru Zhao,

    1. Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 (China)
    Search for more papers by this author
  • Meiling Ruan,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 (China)
    Search for more papers by this author
  • Yonglian Zhang,

    1. Institute of Biochemistry and Cell Biology Shanghai Institute for Biological Sciences Chinese Academy of Sciences Shanghai 200031 (China)
    Search for more papers by this author
  • Jianlin Shi

    Corresponding author
    1. Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 (China)
    2. State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 (China)
    • Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 (China).
    Search for more papers by this author

Abstract

Novel, thiol-functionalized, and superparamagnetic, silica composite nanospheres (SH-SSCNs) with diameters smaller than 100 nm are successfully fabricated through the self-assembly of Fe3O4 nanoparticles and polystyrene100-block-poly(acrylic acid)16 and a subsequent sol-gel process. The size and magnetic properties of the SH-SSCNs can be easily tuned by simply varying the initial concentrations of the magnetite nanoparticles in the oil phase. By incorporating fluorescent dye molecules into the silica network, the composite nanospheres can be further fluorescent-functionalized. The toxicity of the SH-SSCNs is evaluated by choosing three typical cell lines (HUVEC, RAW264.7, and A549) as model cells, and no toxic effects are observed. It is also demonstrated that SH-SSCNs can be used as a new class of magnetic resonance imaging (MRI) probes, having a remarkably high spin–spin (T2) relaxivity (r2* = 176.1 mM−1 S−1). The combination of the sub-100-nm particle size, monodispersity in aqueous solution, superparamagnetism, and fluorescent properties of the SH-SSCNs, as well as the non-cytotoxicity in vitro, provides a novel and potential candidate for an earlier MRI diagnostic method of cancer.

Ancillary