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Triplex Au–Ag–C Core–Shell Nanoparticles as a Novel Raman Label

  1. Aiguo Shen1,
  2. Lifang Chen2,
  3. Wei Xie1,
  4. Juncheng Hu3,
  5. Ao Zeng1,
  6. Ryan Richards4,
  7. Jiming Hu1,*

Article first published online: 16 FEB 2010

DOI: 10.1002/adfm.200901847

Issue

Advanced Functional Materials

Advanced Functional Materials

Volume 20, Issue 6, pages 969–975, March 24, 2010

Additional Information

How to Cite

Shen, A., Chen, L., Xie, W., Hu, J., Zeng, A., Richards, R. and Hu, J. (2010), Triplex Au–Ag–C Core–Shell Nanoparticles as a Novel Raman Label. Adv. Funct. Mater., 20: 969–975. doi: 10.1002/adfm.200901847

Author Information

  1. 1

    Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 (PR China)

  2. 2

    State Key Laboratory of Chemical Engineering East China University of Science and Technology Shanghai 200237 (PR China)

  3. 3

    College of Chemistry and Materials South-Central University for Nationalities Wuhan 430074 (PR China)

  4. 4

    Department of Chemistry and Geochemistry Colorado School of Mines Golden, CO 80401 (USA)

*Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 (PR China).

Publication History

  1. Issue published online: 22 MAR 2010
  2. Article first published online: 16 FEB 2010
  3. Manuscript Revised: 4 NOV 2009
  4. Manuscript Received: 1 OCT 2009

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Keywords:

  • carbon;
  • core–shell nanoparticles;
  • noble metals;
  • biomedical applications

Abstract

Monodispersed, readily-grafted, and biocompatible surface-enhanced Raman spectroscopic (SERS) tagging materials are developed; they are composed of bimetallic Au@Ag nanoparticles (NPs) for optical enhancement, a reporter molecule for spectroscopic signature, and a carbon shell for protection and bioconjugation. A controllable and convenient hydrothermal synthetic route is presented to synthesize the layer-by-layer triplex Au–Ag–C core–shell NPs, which can incorporate the Raman-active label 4-mercapto benzoic acid (4-MBA). The obtained gold seed–silver coated particles can be coated further with a thickness-controlled carbon shell to form colloidal carbon-encapsulated Aucore/Agshell spheres with a monodisperse size distribution. Furthermore, these SERS-active spheres demonstrated interesting properties as a novel Raman tag for quantitative immunoassays. The results suggest such SERS tags can be used for multiplex and ultrasensitive detection of biomolecules as well as nontoxic, in vivo molecular imaging of animal or plant tissues.

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