Get access

Synthesis of Magnetic, Up-Conversion Luminescent, and Mesoporous Core–Shell-Structured Nanocomposites as Drug Carriers

Authors

  • Shili Gai,

    1. College of Material Science and Chemical Engineering Harbin Engineering University Harbin 150001 (P. R. China)
    Search for more papers by this author
  • Piaoping Yang,

    Corresponding author
    1. College of Material Science and Chemical Engineering Harbin Engineering University Harbin 150001 (P. R. China)
    • College of Material Science and Chemical Engineering Harbin Engineering University Harbin 150001 (P. R. China).
    Search for more papers by this author
  • Chunxia Li,

    1. State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 (P. R. China)
    Search for more papers by this author
  • Wenxin Wang,

    1. College of Material Science and Chemical Engineering Harbin Engineering University Harbin 150001 (P. R. China)
    Search for more papers by this author
  • Yunlu Dai,

    1. State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 (P. R. China)
    Search for more papers by this author
  • Na Niu,

    1. College of Material Science and Chemical Engineering Harbin Engineering University Harbin 150001 (P. R. China)
    Search for more papers by this author
  • Jun Lin

    Corresponding author
    1. State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 (P. R. China)
    • State Key laboratory of Rare Earth Resource utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 (P. R. China).
    Search for more papers by this author

Abstract

The synthesis (by a facile two-step sol–gel process), characterization, and application in controlled drug release is reported for monodisperse core–shell-structured Fe3O4@nSiO2@mSiO2@NaYF4: Yb3+, Er3+/Tm3+ nanocomposites with mesoporous, up-conversion luminescent, and magnetic properties. The nanocomposites show typical ordered mesoporous characteristics and a monodisperse spherical morphology with narrow size distribution (around 80 nm). In addition, they exhibit high magnetization (38.0 emu g−1, thus it is possible for drug targeting under a foreign magnetic field) and unique up-conversion emission (green for Yb3+/Er3+ and blue for Yb3+/Tm3+) under 980 nm laser excitation even after loading with drug molecules. Drug release tests suggest that the multifunctional nanocomposites have a controlled drug release property. Interestingly, the up-conversion emission intensity of the multifunctional carrier increases with the released amount of model drug, thus allowing the release process to be monitored and tracked by the change of photoluminescence intensity. This composite can act as a multifunctional drug carrier system, which can realize the targeting and monitoring of drugs simultaneously.

Get access to the full text of this article

Ancillary