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Mussel-Inspired Polydopamine Coating as a Universal Route to Hydroxyapatite Crystallization

Authors

  • Jungki Ryu,

    1. Department of Materials Science and Engineering, KAIST Institute for the BioCentury (KIB) and the NanoCentury (KINC), Korea Advanced Institute of Science and Technology (KAIST) 335 Science Road, Daejeon 305-701 (Republic of Korea)
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  • Sook Hee Ku,

    1. Department of Materials Science and Engineering, KAIST Institute for the BioCentury (KIB) and the NanoCentury (KINC), Korea Advanced Institute of Science and Technology (KAIST) 335 Science Road, Daejeon 305-701 (Republic of Korea)
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  • Haeshin Lee,

    Corresponding author
    1. Department of Chemistry, Molecular-Level Interface Research Center, KAIST Institute for the BioCentury (KIB) and the NanoCentury (KINC), Korea Advanced Institute of Science and Technology (KAIST) 335 Science Road, Daejeon 305-701 (Republic of Korea)
    • Department of Chemistry, Molecular-Level Interface Research Center, KAIST Institute for the BioCentury (KIB) and the NanoCentury (KINC), Korea Advanced Institute of Science and Technology (KAIST) 335 Science Road, Daejeon 305-701 (Republic of Korea)
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  • Chan Beum Park

    Corresponding author
    1. Department of Materials Science and Engineering, KAIST Institute for the BioCentury (KIB) and the NanoCentury (KINC), Korea Advanced Institute of Science and Technology (KAIST) 335 Science Road, Daejeon 305-701 (Republic of Korea)
    • Department of Materials Science and Engineering, KAIST Institute for the BioCentury (KIB) and the NanoCentury (KINC), Korea Advanced Institute of Science and Technology (KAIST) 335 Science Road, Daejeon 305-701 (Republic of Korea)
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Abstract

Bone tissue is a complex biocomposite material with a variety of organic (e.g., proteins, cells) and inorganic (e.g., hydroxyapatite crystals) components hierarchically organized with nano/microscale precision. Based on the understanding of such hierarchical organization of bone tissue and its unique mechanical properties, efforts are being made to mimic these organic–inorganic hybrid biocomposites. A key factor for the successful designing of complex, hybrid biomaterials is the facilitation and control of adhesion at the interfaces, as many current synthetic biomaterials are inert, lacking interfacial bioactivity. In this regard, researchers have focused on controlling the interface by surface modifications, but the development of a simple, unified way to biofunctionalize diverse organic and inorganic materials remains a critical challenge. Here, a universal biomineralization route, called polydopamine-assisted hydroxyapatite formation (pHAF), that can be applied to virtually any type and morphology of scaffold materials is demonstrated. Inspired by the adhesion mechanism of mussels, the pHAF method can readily integrate hydroxyapatites on ceramics, noble metals, semiconductors, and synthetic polymers, irrespective of their size and morphology (e.g., porosity and shape). Surface-anchored catecholamine moieties in polydopamine enriches the interface with calcium ions, facilitating the formation of hydroxyapatite crystals that are aligned to the c-axes, parallel to the polydopamine layer as observed in natural hydroxyapatites in mineralized tissues. This universal surface biomineralization can be an innovative foundation for future tissue engineering.

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