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Cell Migration: Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy (Adv. Funct. Mater. 10/2009)

  1. Deok-Ho Kim1,
  2. Chang-Ho Seo2,
  3. Karam Han1,
  4. Keon Woo Kwon2,
  5. Andre Levchenko1,*,
  6. Kahp-Yang Suh2,*

Article first published online: 18 MAY 2009

DOI: 10.1002/adfm.200990041

Issue

Advanced Functional Materials

Advanced Functional Materials

Additional Information

How to Cite

Kim, D.-H., Seo, C.-H., Han, K., Kwon, K. W., Levchenko, A. and Suh, K.-Y. (2009), Cell Migration: Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy (Adv. Funct. Mater. 10/2009). Adv. Funct. Mater., 19: n/a. doi: 10.1002/adfm.200990041

Author Information

  1. 1

    Department of Biomedical Engineering Johns Hopkins University Baltimore, MD 21218 (USA)

  2. 2

    School of Mechanical and Aerospace Engineering and the Institute of Bioengineering Seoul National University Seoul 151-742 (Korea)

*Department of Biomedical Engineering Johns Hopkins University Baltimore, MD 21218 (USA).

Publication History

  1. Issue published online: 18 MAY 2009
  2. Article first published online: 18 MAY 2009

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Keywords:

  • cell migration;
  • gradients;
  • micropatterns;
  • topography
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A novel microtextured cell substrate with variable local density and anisotropy as a platform for guided cell migration is presented by A. Levchenko, K.-Y. Suh, et al. on page 1579. A simple, scalable, and cost-effective technique, capillary force lithography, is used to fabricate precise microtopographic features on an optically transparent glass coverslip. Live cell motility is found to be extremely sensitive to variation in the local density and anisotropy of rectangular lattices, with cell elongation and speed decreasing on a symmetric lattice. Cells integrate orthogonal contact guidance cues when determining the direction of their orientation and movement.

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