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Fluorescent Imaging: Surface Modification of Exfoliated Layered Gadolinium Hydroxide for the Development of Multimodal Contrast Agents for MRI and Fluorescence Imaging (Adv. Funct. Mater. 21/2009)

Authors

  • Young-su Yoon,

    1. Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea)
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  • Byung-Il Lee,

    1. Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea)
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  • Kyung Sig Lee,

    1. Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea)
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  • Geun Ho Im,

    1. Department of Radiology, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 (Korea)
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  • Song-Ho Byeon,

    Corresponding author
    1. Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea)
    • Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea).
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  • Jung Hee Lee,

    Corresponding author
    1. Department of Radiology, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 (Korea)
    • Department of Radiology, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 (Korea)
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  • In Su Lee

    Corresponding author
    1. Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea)
    • Department of Applied Chemistry, College of Applied Science Kyung Hee University Gyeonggi-do 446-701 (Korea).
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Abstract

original image

The synthesis of a new stable colloid of fluorescent LGdH layers through a newly developed surface modification method is reported by Y.-S. Yoon et al. on page 3375. This new method involves layer exfoliation, anion exchange, and PEG coating. The efficient MRI contrast-enhancement of these LGdH layers, both in vitro and in vivo, demonstrates their potential utility as a multimodal probe combining optical and MR imaging.

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