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Chemiluminescence-Generating Nanoreactor Formulation for Near-Infrared Imaging of Hydrogen Peroxide and Glucose Level in vivo

Authors

  • Chang-Keun Lim,

    1. Biomedical Science Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seoul 136–791 (Korea)
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  • Yong-Deok Lee,

    1. Biomedical Science Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seoul 136–791 (Korea)
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  • Jinhee Na,

    1. Biomedical Science Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seoul 136–791 (Korea)
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  • Jung Min Oh,

    1. Division of Analytical Bio-imaging, Chuncheon Center, Korea Basic Science Institute, 192–1 Hyoja-2-dong, Chuncheon, Gangwon-do 200–701 (Korea)
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  • Song Her,

    1. Division of Analytical Bio-imaging, Chuncheon Center, Korea Basic Science Institute, 192–1 Hyoja-2-dong, Chuncheon, Gangwon-do 200–701 (Korea)
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  • Kwangmeyung Kim,

    1. Biomedical Science Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seoul 136–791 (Korea)
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  • Kuiwon Choi,

    1. Biomedical Science Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seoul 136–791 (Korea)
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  • Sehoon Kim,

    Corresponding author
    1. Biomedical Science Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seoul 136–791 (Korea)
    • Biomedical Science Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seoul 136–791 (Korea).
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  • Ick Chan Kwon

    1. Biomedical Science Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seoul 136–791 (Korea)
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Abstract

Water-dispersed all-in-one nanoprobes composed of densely integrated peroxyoxalate fuel and a cyanine dye are formulated to optimize the nanoscopic chemiluminescence reaction. It is demonstrated that the chemiluminescent nanoformulation can generate bright near-infrared signal in response to external hydrogen peroxide that is biologically implicated with cell signaling and diseases. Successful imaging of endogenously overproduces hydrogen peroxide and indirect determination of glucose level in vivo with the chemiluminescent nanoprobes offers an opportunity for early diagnosis of diseases.

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