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Electrodeposition on Nanofibrous Polymer Scaffolds: Rapid Mineralization, Tunable Calcium Phosphate Composition and Topography

Authors

  • Chuanglong He,

    1. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, 48109, USA
    2. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry and Chemical Engineering and Biological Engineering, Donghua University, Shanghai, 201620, P. R. China
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  • Guiyong Xiao,

    1. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, 48109, USA
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  • Xiaobing Jin,

    1. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, 48109, USA
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  • Chenghui Sun,

    1. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, 48109, USA
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  • Peter X. Ma

    Corresponding author
    1. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, 48109, USA
    2. Department of Biomedical Engineering, Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI, 48109, USA
    • Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, 48109, USA.
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Abstract

A straightforward, fast and versatile technique to fabricate mineralized nanofibrous polymer scaffolds for bone regeneration is developed. Nanofibrous poly(L-lactic acid) scaffolds are fabricated using both electrospinning and phase separation techniques. An electrodeposition process is designed to deposit calcium phosphate on the nanofibrous scaffolds. Such scaffolds contain a high quality mineral coating on the fiber surface and have surface topography and chemical composition that are tunable by varying the processing parameters. These scaffolds can mimic the composition and structure of the natural bone extracellular matrix and provide a more biocompatible interface for bone regeneration.

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