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Doxorubicin Nanocarriers Based on Magnetic Colloids with a Bio-polyelectrolyte Corona and High Non-linear Optical Response: Synthesis, Characterization, and Properties

Authors

  • Aristides Bakandritsos,

    Corresponding author
    1. Materials Science Department, University of Patras, Rion 26504, Greece
    • Materials Science Department, University of Patras, Rion 26504, Greece
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  • George Mattheolabakis,

    1. School of Pharmacy University of Patras, Rion 26504, Greece
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  • George Chatzikyriakos,

    1. Department of Physics School of Natural Sciences, University of Patras, Rio 26504 Patras, Greece, Institute of Chemical Engineering and High Temperature Chemical Processes (ICEHT), Foundation for Research and Technology-Hellas (FORTH), 26504 Patras, Geece
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  • Tamas Szabo,

    1. Department of Physical Chemistry and Materials Science, University of Szeged, Aradi Vértanúk tere 1, H-6720 Szeged, Hungary
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  • Vasilis Tzitzios,

    1. Institute of Materials Science, N.C.S.R. ‘‘Demokritos’’ Agia Paraskevi, 15310, Athens, Greece
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  • Dimitris Kouzoudis,

    1. Engineering Sciences Department, University of Patras, 26504 Rio, Patra, Greece
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  • Stelios Couris,

    Corresponding author
    1. Department of Physics School of Natural Sciences, University of Patras, Rio 26504 Patras, Greece, Institute of Chemical Engineering and High Temperature Chemical Processes (ICEHT), Foundation for Research and Technology-Hellas (FORTH), 26504 Patras, Geece
    • Department of Physics School of Natural Sciences, University of Patras, Rio 26504 Patras, Greece, Institute of Chemical Engineering and High Temperature Chemical Processes (ICEHT), Foundation for Research and Technology-Hellas (FORTH), 26504 Patras, Geece.
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  • Konstantinos Avgoustakis

    1. School of Pharmacy University of Patras, Rion 26504, Greece
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Abstract

Magnetic drug nanocarriers are synthesized following an arrested mineralization of magnetic spinel iron oxides in the presence of the biopolymer of sodium carboxymethylcellulose. Based on the experimental results, the polyelectrolyte corona probably attains a brushlike configuration around the magnetic particles. The inner core of these colloids may be constituted of polymer-associated nanocrystallites, forming nanogel colloids. The hybrid colloids are endowed with a high loading capacity for the anticancer agent doxorubicin and pronounced pH responsiveness. They also display a dramatic increase in non-linear optical response as compared to previous studies of similar materials. Furthermore, as cell studies indicate, the blank nanocarriers are cytocompatible and the drug retains its activity after loading in the nanocarriers.

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