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Electrochemically Stimulated Release from Liposomes Embedded in a Polyelectrolyte Multilayer

Authors

  • Norma Graf,

    1. Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zürich, Gloriastrasse 35, 8092 Zürich, Switzerland
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  • Francesco Albertini,

    1. Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zürich, Gloriastrasse 35, 8092 Zürich, Switzerland
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  • Tristan Petit,

    1. Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zürich, Gloriastrasse 35, 8092 Zürich, Switzerland
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  • Erik Reimhult,

    1. Institut für Nanobiotechnologie (NBT), Muthgasse 11/II, A-1190 Wien, Austria
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  • Janos Vörös,

    1. Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zürich, Gloriastrasse 35, 8092 Zürich, Switzerland
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  • Tomaso Zambelli

    Corresponding author
    1. Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zürich, Gloriastrasse 35, 8092 Zürich, Switzerland
    • Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zürich, Gloriastrasse 35, 8092 Zürich, Switzerland.
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Abstract

Triggered release of an entrapped dye from vesicles embedded in a polyelectrolyte multilayer (PEM), as a consequence of the electrochemically induced local pH change in the vicinity of the electrode, is reported. The PEM was deposited on an indium tin oxide (ITO) electrode wherein lipid vesicles filled with a fluorescent dye were embedded. The use of vesicles with a strong negative charge and the polyelectrolyte species of the PEM matrix with a polycation as topmost layer enabled the generation of a stable layer of liposomes in the PEM.

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